LGALS2

Protein identityUniProt · HPA

UniProt accession

P05162

Gene

LGALS2

Ensembl

ENSG00000100079

Chromosome

22

Canonical length

132 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Mitochondria

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

132 residues, UniProt reviewed canonical sequence.

>P05162|LGALS2
     1  MTGELEVKNM DMKPGSTLKI TGSIADGTDG FVINLGQGTD KLNLHFNPRF SESTIVCNSL
    61  DGSNWGQEQR EDHLCFSPGS EVKFTVTFES DKFKVKLPDG HELTFPNRLG HSHLSYLSVR
   121  GGFNMSSFKL KE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LGALS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Unknown

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.26

Highest tissue expression

315 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for LGALS2 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.48

gnomAD pLI

0.02

gnomAD missense Z

-0.36

DepMap mean gene effect

0

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell-cell adhesion
• positive regulation of apoptotic process
• positive regulation of inflammatory response
• T cell homeostasis

Molecular functions

• carbohydrate binding
• galactoside binding

Cellular components

• galectin complex

Protein domainsUniProt · Pfam · InterPro

• Galectin, carbohydrate recognition domain
• Concanavalin A-like lectin/glucanase domain superfamily
• Galectin-like
• Galactoside-binding lectin

KeywordsUniProt

• Lectin

InteractionsUniProt · HPA

Protein binding partners of LGALS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• LTA