Seroatlas · Human Serome Atlas

LPAR2

Lysophosphatidic acid receptor 2

Also known as: EDG-4, EDG4, LPA2, LPAR2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HBW0
Gene
LPAR2
Ensembl
ENSG00000064547
Chromosome
19
Canonical length
348 aa
Protein class
G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

348 residues, UniProt reviewed canonical sequence.

>Q9HBW0|LPAR2
     1  MGQCYYNETI GFFYNNSGKE LSSHWRPKDV VVVALGLTVS VLVLLTNLLV IAAIASNRRF
    61  HQPIYYLLGN LAAADLFAGV AYLFLMFHTG PRTARLSLEG WFLRQGLLDT SLTASVATLL
   121  AIAVERHRSV MAVQLHSRLP RGRVVMLIVG VWVAALGLGL LPAHSWHCLC ALDRCSRMAP
   181  LLSRSYLAVW ALSSLLVFLL MVAVYTRIFF YVRRRVQRMA EHVSCHPRYR ETTLSLVKTV
   241  VIILGAFVVC WTPGQVVLLL DGLGCESCNV LAVEKYFLLL AEANSLVNAA VYSCRDAEMR
   301  RTFRRLLCCA CLRQSTRESV HYTSSAQGGA STRIMLPENG HPLMDSTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LPAR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
74 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 74 nTPM
  • bone marrow: 49 nTPM
  • testis: 49 nTPM
  • stomach: 32 nTPM
  • lung: 28 nTPM
  • pancreas: 27 nTPM

Single-cell type

  • neutrophils: 159 nCPM
  • neutrophil progenitors: 39 nCPM
  • sertoli cells: 38 nCPM
  • foveolar cells: 27 nCPM
  • mucous neck cells: 26 nCPM
  • esophageal apical cells: 24 nCPM

Immune cell

  • T-reg: 26 nTPM
  • memory CD4 T-cell: 21 nTPM
  • naive CD4 T-cell: 18 nTPM
  • MAIT T-cell: 16 nTPM
  • naive CD8 T-cell: 14 nTPM
  • memory CD8 T-cell: 12 nTPM

Brain region

  • hypothalamus: 13 nTPM
  • cerebral cortex: 12 nTPM
  • white matter: 10 nTPM
  • medulla oblongata: 9.8 nTPM
  • pons: 9.7 nTPM
  • choroid plexus: 9.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.87
gnomAD pLI
0.04
gnomAD missense Z
1.85

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LPAR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LPAR2 as an antibody target. Whether an autoantibody or antibody against LPAR2 could matter depends on whether native LPAR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LPAR2 is annotated at the cell surface, where native LPAR2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LPAR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LPAR2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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