Seroatlas · Human Serome Atlas

TMEM218

Transmembrane protein 218

Also known as: TM218_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A2RU14
Gene
TMEM218
Ensembl
ENSG00000150433
Chromosome
11
Canonical length
115 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to be located in cilium and membrane. Implicated in Joubert syndrome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

115 residues, UniProt reviewed canonical sequence.

>A2RU14|TMEM218
     1  MAGTVLGVGA GVFILALLWV AVLLLCVLLS RASGAARFSV IFLFFGAVII TSVLLLFPRA
    61  GEFPAPEVEV KIVDDFFIGR YVLLAFLSAI FLGGLFLVLI HYVLEPIYAK PLHSY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM218 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
3
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 17 nTPM
  • adrenal gland: 15 nTPM
  • spleen: 14 nTPM
  • endometrium: 14 nTPM
  • cervix: 13 nTPM
  • kidney: 13 nTPM

Single-cell type

  • hofbauer cells: 52 nCPM
  • fallopian tube ciliated cells: 51 nCPM
  • decidual stromal cells: 47 nCPM
  • respiratory ciliated cells: 46 nCPM
  • esophageal apical cells: 37 nCPM
  • cytotrophoblasts: 36 nCPM

Immune cell

  • myeloid DC: 48 nTPM
  • basophil: 44 nTPM
  • plasmacytoid DC: 41 nTPM
  • classical monocyte: 40 nTPM
  • NK-cell: 33 nTPM
  • intermediate monocyte: 32 nTPM

Brain region

  • white matter: 9.2 nTPM
  • medulla oblongata: 8.9 nTPM
  • spinal cord: 8.2 nTPM
  • midbrain: 8 nTPM
  • hypothalamus: 7.7 nTPM
  • basal ganglia: 7.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TMEM218.

Disease | AllUniProt

Conditions TMEM218 is implicated in, by any mechanism.

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 35 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.83
gnomAD pLI
0
gnomAD missense Z
0.74
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Transmembrane protein 218
  • Transmembrane protein 218, N-terminal domain
  • Transmembrane protein 218, N-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM218 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM218 as an antibody target. Whether an autoantibody or antibody against TMEM218 could matter depends on whether native TMEM218 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM218 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM218 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM218. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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