Seroatlas · Human Serome Atlas

KRI1

Protein KRI1 homolog

Also known as: FLJ12949, KRI1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N9T8
Gene
KRI1
Ensembl
ENSG00000129347
Chromosome
19
Canonical length
703 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli

OverviewNCBI Gene

This gene overlaps with the gene for cysteine endopeptidase AUT-like 4 in a head-to-tail orientation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

703 residues, UniProt reviewed canonical sequence.

>Q8N9T8|KRI1
     1  MPEPRGSSQL RVNAAFAARY NRYREREELQ RLKDRYGDRD SSSDSSSESD SSDERVEFDP
    61  QQERDFYKTL SLLKKKDPRI YQKDATFYNR TASSSDSEED PEALEKQKKV RPMYLKDYER
   121  KVILEKAGKY VDEENSDGET SNHRLQETSS QSYVEEQKQL KESFRAFVED SEDEDGAGEG
   181  GSSLLQKRAK TRQEKAQEEA DYIEWLKGQK EIRNPDSLKE LTHLKEYWND PELDEGERFL
   241  RDYILNKRYE EEEEEEEDEE EMEEEEGVHG PPVQLAVDDS SDEGELFLKK QEDFEQKYNF
   301  RFEEPDSASV KTYPRSIASS VRRKDERRKE KREETRERKK REKAKKQEEL KQLKNLKRKE
   361  ILAKLEKLRK VTGNEMLGLE EGDLEDDFDP AQHDQLMQKC FGDEYYGAVE EEKPQFEEEE
   421  GLEDDWNWDT WDGPEQEGDW SQQELHCEDP NFNMDADYDP SQPRKKKREA PLTGKKKRKS
   481  PFAAAVGQEK PVFEPGDKTF EEYLDEYYRL DYEDIIDDLP CRFKYRTVVP CDFGLSTEEI
   541  LAADDKELNR WCSLKKTCMY RSEQEELRDK RAYSQKAQNS WKKRQVFKSL CREEAETPAE
   601  ATGKPQRDEA GPQRQLPALD GSLMGPESPP AQEEEAPVSP HKKPAPQKRR RAKKARLLGP
   661  TVMLGGCEFS RQRLQAFGLN PKRLHFRQLG RQRRKQQGPK NSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRI1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • retina: 31 nTPM
  • thymus: 28 nTPM
  • spleen: 22 nTPM
  • skeletal muscle: 21 nTPM
  • lymph node: 21 nTPM
  • skin: 20 nTPM

Single-cell type

  • megakaryocyte progenitors: 52 nCPM
  • rod photoreceptor cells: 50 nCPM
  • megakaryocyte-erythroid progenitors: 38 nCPM
  • erythrocyte progenitors: 37 nCPM
  • megakaryocytes: 37 nCPM
  • pdcs: 34 nCPM

Immune cell

  • plasmacytoid DC: 16 nTPM
  • gdT-cell: 12 nTPM
  • MAIT T-cell: 11 nTPM
  • NK-cell: 10 nTPM
  • memory CD8 T-cell: 9.7 nTPM
  • naive CD8 T-cell: 9.5 nTPM

Brain region

  • hypothalamus: 9.5 nTPM
  • white matter: 9 nTPM
  • choroid plexus: 8.7 nTPM
  • medulla oblongata: 8.3 nTPM
  • cerebral cortex: 8.2 nTPM
  • basal ganglia: 7.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.88
gnomAD pLI
0
gnomAD missense Z
0.14
DepMap mean gene effect
-1.03
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

  • LSU-rRNA)
  • endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA
  • 5.8S rRNA

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • KRR1 interacting protein 1
  • Kri1-like, C-terminal
  • KRI1-like family
  • KRI1-like family C-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KRI1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRI1 as an antibody target. Whether an autoantibody or antibody against KRI1 could matter depends on whether native KRI1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRI1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRI1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KRI1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...