Seroatlas · Human Serome Atlas

KLF3

Krueppel-like factor 3

Also known as: BKLF, KLF3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P57682
Gene: KLF3
Ensembl: ENSG00000109787
Chromosome: 4
Canonical length: 345 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

345 residues, UniProt reviewed canonical sequence.

>P57682|KLF3
     1  MLMFDPVPVK QEAMDPVSVS YPSNYMESMK PNKYGVIYST PLPEKFFQTP EGLSHGIQME
    61  PVDLTVNKRS SPPSAGNSPS SLKFPSSHRR ASPGLSMPSS SPPIKKYSPP SPGVQPFGVP
   121  LSMPPVMAAA LSRHGIRSPG ILPVIQPVVV QPVPFMYTSH LQQPLMVSLS EEMENSSSSM
   181  QVPVIESYEK PISQKKIKIE PGIEPQRTDY YPEEMSPPLM NSVSPPQALL QENHPSVIVQ
   241  PGKRPLPVES PDTQRKRRIH RCDYDGCNKV YTKSSHLKAH RRTHTGEKPY KCTWEGCTWK
   301  FARSDELTRH FRKHTGIKPF QCPDCDRSFS RSDHLALHRK RHMLV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLF3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 90 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 90 nTPM
skin: 59 nTPM
esophagus: 50 nTPM
rectum: 45 nTPM
stomach: 44 nTPM
colon: 42 nTPM

Single-cell type

esophageal apical cells: 977 nCPM
esophageal suprabasal cells: 416 nCPM
platelets: 344 nCPM
colonocytes: 338 nCPM
goblet cells: 324 nCPM
respiratory secretory cells: 313 nCPM

Immune cell

eosinophil: 17 nTPM
neutrophil: 14 nTPM
non-classical monocyte: 13 nTPM
basophil: 11 nTPM
naive CD4 T-cell: 9.7 nTPM
T-reg: 8.4 nTPM

Brain region

white matter: 46 nTPM
medulla oblongata: 44 nTPM
basal ganglia: 40 nTPM
midbrain: 40 nTPM
thalamus: 37 nTPM
cerebellum: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.43
gnomAD pLI: 0.83
gnomAD missense Z: 1.56
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KLF3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLF3 as an antibody target. Whether an autoantibody or antibody against KLF3 could matter depends on whether native KLF3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLF3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLF3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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