Seroatlas · Human Serome Atlas

RCCD1

RCC1 domain-containing protein 1

Also known as: MGC14386, RCCD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NED2
Gene: RCCD1
Ensembl: ENSG00000166965
Chromosome: 15
Canonical length: 376 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to be involved in chromatin organization. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

376 residues, UniProt reviewed canonical sequence.

>A6NED2|RCCD1
     1  MAEERPGAWF GFGFCGFGQE LGSGRGRQVH SPSPLRAGVD ICRVSASWSY TAFVTRGGRL
    61  ELSGSASGAA GRCKDAWASE GLLAVLRAGP GPEALLQVWA AESALRGEPL WAQNVVPEAE
   121  GEDDPAGEAQ AGRLPLLPCA RAYVSPRAPF YRPLAPELRA RQLELGAEHA LLLDAAGQVF
   181  SWGGGRHGQL GHGTLEAELE PRLLEALQGL VMAEVAAGGW HSVCVSETGD IYIWGWNESG
   241  QLALPTRNLA EDGETVAREA TELNEDGSQV KRTGGAEDGA PAPFIAVQPF PALLDLPMGS
   301  DAVKASCGSR HTAVVTRTGE LYTWGWGKYG QLGHEDTTSL DRPRRVEYFV DKQLQVKAVT
   361  CGPWNTYVYA VEKGKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RCCD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 11 nTPM
pancreas: 9 nTPM
adrenal gland: 8.6 nTPM
ovary: 7.2 nTPM
skin: 7 nTPM
liver: 6.6 nTPM

Single-cell type

oocytes: 97 nCPM
retinal pigment epithelial cells: 43 nCPM
enteric transient amplifying cells: 39 nCPM
megakaryocytes: 37 nCPM
erythrocyte progenitors: 35 nCPM
esophageal basal cells: 30 nCPM

Immune cell

memory B-cell: 0.8 nTPM
naive CD4 T-cell: 0.8 nTPM
memory CD8 T-cell: 0.7 nTPM
plasmacytoid DC: 0.7 nTPM
intermediate monocyte: 0.6 nTPM
T-reg: 0.6 nTPM

Brain region

cerebellum: 10 nTPM
choroid plexus: 9.6 nTPM
cerebral cortex: 7.9 nTPM
basal ganglia: 7.7 nTPM
hippocampal formation: 7.2 nTPM
pons: 6.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.54
gnomAD pLI: 0
gnomAD missense Z: 0.21
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

chromatin organization

Cellular components

Protein domainsUniProt · Pfam · InterPro

Regulator of chromosome condensation, RCC1
Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
Regulator of chromosome condensation (RCC1) repeat
RCC1 domain-containing protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RCCD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

KDM8

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RCCD1 as an antibody target. Whether an autoantibody or antibody against RCCD1 could matter depends on whether native RCCD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RCCD1 is annotated at the cell surface, where native RCCD1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RCCD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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