Seroatlas · Human Serome Atlas

GNG4

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4

Also known as: GBG4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P50150
Gene: GNG4
Ensembl: ENSG00000168243
Chromosome: 1
Canonical length: 75 aa
Protein class: Predicted intracellular proteins, RAS pathway related proteins

OverviewNCBI Gene

Predicted to enable G-protein beta-subunit binding activity. Involved in negative regulation of cell growth. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

75 residues, UniProt reviewed canonical sequence.

>P50150|GNG4
     1  MKEGMSNNST TSISQARKAV EQLKMEACMD RVKVSQAAAD LLAYCEAHVR EDPLIIPVPA
    61  SENPFREKKF FCTIL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GNG4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 37 nTPM
ovary: 31 nTPM
pituitary gland: 30 nTPM
amygdala: 28 nTPM
cerebral cortex: 27 nTPM
prostate: 22 nTPM

Single-cell type

lactotrophs: 175 nCPM
somatotrophs: 156 nCPM
prostatic glandular cells: 98 nCPM
gonadotrophs: 92 nCPM
neuroendocrine cells: 91 nCPM
pancreatic islet cells: 90 nCPM

Immune cell

basophil: 0.6 nTPM
memory CD4 T-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
total PBMC: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

hypothalamus: 86 nTPM
midbrain: 59 nTPM
pons: 53 nTPM
cerebral cortex: 52 nTPM
medulla oblongata: 45 nTPM
amygdala: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.71
gnomAD pLI: 0.16
gnomAD missense Z: 0.68
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

G-protein beta-subunit binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GNG4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

KCNK1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GNG4 as an antibody target. Whether an autoantibody or antibody against GNG4 could matter depends on whether native GNG4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GNG4 is annotated at the cell surface, where native GNG4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GNG4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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