Seroatlas · Human Serome Atlas

INTS12

Integrator complex subunit 12

Also known as: INT12, INT12_HUMAN, PHF22, SBBI22

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96CB8
Gene
INTS12
Ensembl
ENSG00000138785
Chromosome
4
Canonical length
462 aa
Protein class
Cancer-related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies,Plasma membrane,Cytosol

OverviewNCBI Gene

INTS12 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

462 residues, UniProt reviewed canonical sequence.

>Q96CB8|INTS12
     1  MAATVNLELD PIFLKALGFL HSKSKDSAEK LKALLDESLA RGIDSSYRPS QKDVEPPKIS
    61  STKNISIKQE PKISSSLPSG NNNGKVLTTE KVKKEAEKRP ADKMKSDITE GVDIPKKPRL
   121  EKPETQSSPI TVQSSKDLPM ADLSSFEETS ADDFAMEMGL ACVVCRQMMV ASGNQLVECQ
   181  ECHNLYHRDC HKPQVTDKEA NDPRLVWYCA RCTRQMKRMA QKTQKPPQKP APAVVSVTPA
   241  VKDPLVKKPE TKLKQETTFL AFKRTEVKTS TVISGNSSSA SVSSSVTSGL TGWAAFAAKT
   301  SSAGPSTAKL SSTTQNNTGK PATSSANQKP VGLTGLATSS KGGIGSKIGS NNSTTPTVPL
   361  KPPPPLTLGK TGLSRSVSCD NVSKVGLPSP SSLVPGSSSQ LSGNGNSGTS GPSGSTTSKT
   421  TSESSSSPSA SLKGPTSQES QLNAMKRLQM VKKKAAQKKL KK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INTS12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
29 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 29 nTPM
  • skeletal muscle: 25 nTPM
  • tongue: 24 nTPM
  • liver: 21 nTPM
  • breast: 19 nTPM
  • thymus: 19 nTPM

Single-cell type

  • podocytes: 703 nCPM
  • early spermatids: 190 nCPM
  • pancreatic duct cells: 163 nCPM
  • late primary spermatocytes: 130 nCPM
  • epididymal basal cells: 127 nCPM
  • epicardial cells: 118 nCPM

Immune cell

  • basophil: 61 nTPM
  • plasmacytoid DC: 43 nTPM
  • NK-cell: 42 nTPM
  • eosinophil: 38 nTPM
  • T-reg: 34 nTPM
  • memory B-cell: 33 nTPM

Brain region

  • cerebellum: 22 nTPM
  • hypothalamus: 22 nTPM
  • midbrain: 20 nTPM
  • white matter: 19 nTPM
  • thalamus: 19 nTPM
  • basal ganglia: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.75
gnomAD missense Z
1.35
DepMap mean gene effect
-0.48
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of INTS12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INTS12 as an antibody target. Whether an autoantibody or antibody against INTS12 could matter depends on whether native INTS12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INTS12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label INTS12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/INTS12. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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