Seroatlas · Human Serome Atlas

RNF145

RING finger protein 145

Also known as: FLJ31951, RN145_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96MT1
Gene: RNF145
Ensembl: ENSG00000145860
Chromosome: 5
Canonical length: 663 aa
Protein class: Enzymes, Predicted membrane proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ERAD pathway and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endomembrane system. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

663 residues, UniProt reviewed canonical sequence.

>Q96MT1|RNF145
     1  MAAKEKLEAV LNVALRVPSI MLLDVLYRWD VSSFFQQIQR SSLSNNPLFQ YKYLALNMHY
    61  VGYILSVVLL TLPRQHLVQL YLYFLTALLL YAGHQISRDY VRSELEFAYE GPMYLEPLSM
   121  NRFTTALIGQ LVVCTLCSCV MKTKQIWLFS AHMLPLLARL CLVPLETIVI INKFAMIFTG
   181  LEVLYFLGSN LLVPYNLAKS AYRELVQVVE VYGLLALGMS LWNQLVVPVL FMVFWLVLFA
   241  LQIYSYFSTR DQPASRERLL FLFLTSIAEC CSTPYSLLGL VFTVSFVALG VLTLCKFYLQ
   301  GYRAFMNDPA MNRGMTEGVT LLILAVQTGL IELQVVHRAF LLSIILFIVV ASILQSMLEI
   361  ADPIVLALGA SRDKSLWKHF RAVSLCLFLL VFPAYMAYMI CQFFHMDFWL LIIISSSILT
   421  SLQVLGTLFI YVLFMVEEFR KEPVENMDDV IYYVNGTYRL LEFLVALCVV AYGVSETIFG
   481  EWTVMGSMII FIHSYYNVWL RAQLGWKSFL LRRDAVNKIK SLPIATKEQL EKHNDICAIC
   541  YQDMKSAVIT PCSHFFHAGC LKKWLYVQET CPLCHCHLKN SSQLPGLGTE PVLQPHAGAE
   601  QNVMFQEGTE PPGQEHTPGT RIQEGSRDNN EYIARRPDNQ EGAFDPKEYP HSAKDEAHPV
   661  ESA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF145 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 14
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 69 nTPM

Expression across tissuesHPA

Tissue

lung: 69 nTPM
urinary bladder: 64 nTPM
esophagus: 50 nTPM
placenta: 49 nTPM
tonsil: 45 nTPM
gallbladder: 45 nTPM

Single-cell type

alveolar cells type 2: 665 nCPM
transitional alveolar cells: 607 nCPM
breast lactating cells: 479 nCPM
neutrophil progenitors: 419 nCPM
neutrophils: 418 nCPM
esophageal apical cells: 363 nCPM

Immune cell

eosinophil: 16 nTPM
memory B-cell: 11 nTPM
neutrophil: 9.5 nTPM
T-reg: 6.3 nTPM
naive CD4 T-cell: 5.9 nTPM
naive B-cell: 5.2 nTPM

Brain region

hypothalamus: 48 nTPM
choroid plexus: 45 nTPM
cerebellum: 39 nTPM
basal ganglia: 38 nTPM
cerebral cortex: 38 nTPM
white matter: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.31
gnomAD pLI: 0.98
gnomAD missense Z: 3.59
DepMap mean gene effect: 0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Zinc finger, RING-type
Zinc finger, RING-CH-type
Zinc finger, RING/FYVE/PHD-type
TRC8-like, N-terminal domain
HRD1 family E3 ubiquitin-protein ligases
Ring finger domain
TRC8 N-terminal domain
RNF145, RING finger, H2 subclass

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNF145 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF145 as an antibody target. Whether an autoantibody or antibody against RNF145 could matter depends on whether native RNF145 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF145 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF145 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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