GPR78

Protein identityUniProt · HPA

UniProt accession

Q96P69

Gene

GPR78

Ensembl

ENSG00000155269

Chromosome

4

Canonical length

363 aa

Protein class

G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene belongs to the G protein-coupled receptor family, which contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. This is an orphan receptor, which displays significant level of constitutive activity. Association analysis shows preliminary evidence for the involvement of this gene in susceptibility to bipolar affective disorder and schizophrenia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]

Canonical amino-acid sequenceUniProt

363 residues, UniProt reviewed canonical sequence.

>Q96P69|GPR78
     1  MGPGEALLAG LLVMVLAVAL LSNALVLLCC AYSAELRTRA SGVLLVNLSL GHLLLAALDM
    61  PFTLLGVMRG RTPSAPGACQ VIGFLDTFLA SNAALSVAAL SADQWLAVGF PLRYAGRLRP
   121  RYAGLLLGCA WGQSLAFSGA ALGCSWLGYS SAFASCSLRL PPEPERPRFA AFTATLHAVG
   181  FVLPLAVLCL TSLQVHRVAR RHCQRMDTVT MKALALLADL HPSVRQRCLI QQKRRRHRAT
   241  RKIGIAIATF LICFAPYVMT RLAELVPFVT VNAQWGILSK CLTYSKAVAD PFTYSLLRRP
   301  FRQVLAGMVH RLLKRTPRPA STHDSSLDVA GMVHQLLKRT PRPASTHNGS VDTENDSCLQ
   361  QTH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR78 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

7

Mean surface accessibility (rSASA)

0.34

Highest tissue expression

6.3 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.82

gnomAD pLI

0

gnomAD missense Z

-1.25

DepMap mean gene effect

0.03

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adenylate cyclase-activating G protein-coupled receptor signaling pathway

Molecular functions

• G protein-coupled receptor activity

Cellular components

• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• G protein-coupled receptor, rhodopsin-like
• GPCR, rhodopsin-like, 7TM
• G protein-coupled receptors 26/78-like
• G-protein Coupled Orphan Receptors
• 7 transmembrane receptor (rhodopsin family)

KeywordsUniProt

• Cell membrane
• Disulfide bond
• G-protein coupled receptor
• Membrane
• Receptor
• Transducer
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of GPR78 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• INPP5K