Seroatlas · Human Serome Atlas

INHBE

Inhibin beta E chain

Also known as: activin, INHBE_HUMAN, MGC4638

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P58166
Gene
INHBE
Ensembl
ENSG00000139269
Chromosome
12
Canonical length
350 aa
Protein class
Plasma proteins, Predicted secreted proteins
Subcellular location
Vesicles
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate an inhibin beta subunit. Inhibins have been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. This gene may be upregulated under conditions of endoplasmic reticulum stress, and this protein may inhibit cellular proliferation and growth in pancreas and liver. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

350 residues, UniProt reviewed canonical sequence.

>P58166|INHBE
     1  MRLPDVQLWL VLLWALVRAQ GTGSVCPSCG GSKLAPQAER ALVLELAKQQ ILDGLHLTSR
    61  PRITHPPPQA ALTRALRRLQ PGSVAPGNGE EVISFATVTD STSAYSSLLT FHLSTPRSHH
   121  LYHARLWLHV LPTLPGTLCL RIFRWGPRRR RQGSRTLLAE HHITNLGWHT LTLPSSGLRG
   181  EKSGVLKLQL DCRPLEGNST VTGQPRRLLD TAGHQQPFLE LKIRANEPGA GRARRRTPTC
   241  EPATPLCCRR DHYVDFQELG WRDWILQPEG YQLNYCSGQC PPHLAGSPGI AASFHSAVFS
   301  LLKANNPWPA STSCCVPTAR RPLSLLYLDH NGNVVKTDVP DMVVEACGCS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INHBE can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
134 nTPM

Expression across tissuesHPA

Tissue

  • liver: 134 nTPM
  • skeletal muscle: 1.4 nTPM
  • thyroid gland: 1.3 nTPM
  • pancreas: 0.9 nTPM
  • pituitary gland: 0.9 nTPM
  • cerebellum: 0.6 nTPM

Single-cell type

  • hepatocytes: 43 nCPM
  • retinal bipolar cells: 2.8 nCPM
  • medullary thymic epithelial cells: 2.4 nCPM
  • epicardial cells: 2.3 nCPM
  • rod photoreceptor cells: 2 nCPM
  • bergmann glia: 1.5 nCPM

Immune cell

  • basophil: 0.7 nTPM
  • neutrophil: 0.7 nTPM
  • memory B-cell: 0.2 nTPM
  • plasmacytoid DC: 0.2 nTPM
  • classical monocyte: 0.1 nTPM
  • eosinophil: 0.1 nTPM

Brain region

  • cerebellum: 3.3 nTPM
  • pons: 2.6 nTPM
  • cerebral cortex: 1.4 nTPM
  • medulla oblongata: 1.3 nTPM
  • hypothalamus: 1 nTPM
  • white matter: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.43
gnomAD pLI
0
gnomAD missense Z
0.66
DepMap mean gene effect
-0.39
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INHBE as an antibody target. Whether an autoantibody or antibody against INHBE could matter depends on whether native INHBE is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INHBE is annotated as secreted, so native INHBE circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label INHBE as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/INHBE. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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