Seroatlas · Human Serome Atlas

INHBC

Inhibin beta C chain

Also known as: INHBC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P55103
Gene: INHBC
Ensembl: ENSG00000175189
Chromosome: 12
Canonical length: 352 aa
Protein class: Plasma proteins, Predicted secreted proteins
Subcellular location: Cytosol
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of homodimeric and heterodimeric activin complexes. The heterodimeric complex may function in the inhibition of activin A signaling. Transgenic mice overexpressing this gene exhibit defects in testis, liver and prostate. [provided by RefSeq, Aug 2016]

Canonical amino-acid sequenceUniProt

352 residues, UniProt reviewed canonical sequence.

>P55103|INHBC
     1  MTSSLLLAFL LLAPTTVATP RAGGQCPACG GPTLELESQR ELLLDLAKRS ILDKLHLTQR
    61  PTLNRPVSRA ALRTALQHLH GVPQGALLED NREQECEIIS FAETGLSTIN QTRLDFHFSS
   121  DRTAGDREVQ QASLMFFVQL PSNTTWTLKV RVLVLGPHNT NLTLATQYLL EVDASGWHQL
   181  PLGPEAQAAC SQGHLTLELV LEGQVAQSSV ILGGAAHRPF VAARVRVGGK HQIHRRGIDC
   241  QGGSRMCCRQ EFFVDFREIG WHDWIIQPEG YAMNFCIGQC PLHIAGMPGI AASFHTAVLN
   301  LLKANTAAGT TGGGSCCVPT ARRPLSLLYY DRDSNIVKTD IPDMVVEACG CS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INHBC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 154 nTPM

Expression across tissuesHPA

Tissue

liver: 154 nTPM
testis: 1.1 nTPM
epididymis: 0.7 nTPM
cerebellum: 0.4 nTPM
prostate: 0.3 nTPM
thyroid gland: 0.3 nTPM

Single-cell type

hepatocytes: 45 nCPM
epididymal basal cells: 7.1 nCPM
early primary spermatocytes: 6.3 nCPM
retinal ganglion cells: 3.9 nCPM
epididymal principal cells: 3.8 nCPM
epididymal efferent duct ciliated cells: 3.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 1.3 nTPM
cerebral cortex: 0.7 nTPM
pons: 0.6 nTPM
white matter: 0.6 nTPM
amygdala: 0.4 nTPM
basal ganglia: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
gnomAD missense Z: 1.01
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell surface receptor protein serine/threonine kinase signaling pathway

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INHBC as an antibody target. Whether an autoantibody or antibody against INHBC could matter depends on whether native INHBC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INHBC is annotated as secreted, so native INHBC circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label INHBC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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