Seroatlas · Human Serome Atlas

INHA

Inhibin alpha chain

Also known as: INHA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P05111
Gene
INHA
Ensembl
ENSG00000123999
Chromosome
2
Canonical length
366 aa
Protein class
Predicted secreted proteins
Subcellular location
Golgi apparatus,Vesicles
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate multiple peptide products, including the alpha subunit of the inhibin A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. Mutations in this gene may be associated with male infertility and premature ovarian failure in female human patients. [provided by RefSeq, Aug 2016]

Canonical amino-acid sequenceUniProt

366 residues, UniProt reviewed canonical sequence.

>P05111|INHA
     1  MVLHLLLFLL LTPQGGHSCQ GLELARELVL AKVRALFLDA LGPPAVTREG GDPGVRRLPR
    61  RHALGGFTHR GSEPEEEEDV SQAILFPATD ASCEDKSAAR GLAQEAEEGL FRYMFRPSQH
   121  TRSRQVTSAQ LWFHTGLDRQ GTAASNSSEP LLGLLALSPG GPVAVPMSLG HAPPHWAVLH
   181  LATSALSLLT HPVLVLLLRC PLCTCSARPE ATPFLVAHTR TRPPSGGERA RRSTPLMSWP
   241  WSPSALRLLQ RPPEEPAAHA NCHRVALNIS FQELGWERWI VYPPSFIFHY CHGGCGLHIP
   301  PNLSLPVPGA PPTPAQPYSL LPGAQPCCAA LPGTMRPLHV RTTSDGGYSF KYETVPNLLT
   361  QHCACI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INHA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
109 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 109 nTPM
  • testis: 101 nTPM
  • adrenal gland: 76 nTPM
  • heart muscle: 17 nTPM
  • basal ganglia: 12 nTPM
  • pancreas: 12 nTPM

Single-cell type

  • syncytiotrophoblasts: 444 nCPM
  • granulosa cells: 248 nCPM
  • cardiomyocytes: 106 nCPM
  • ovarian stromal cells: 68 nCPM
  • sertoli cells: 62 nCPM
  • extravillous trophoblasts: 61 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 6.1 nTPM
  • basal ganglia: 4.9 nTPM
  • pons: 4.6 nTPM
  • amygdala: 4.4 nTPM
  • hypothalamus: 4.1 nTPM
  • medulla oblongata: 3.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.02
gnomAD pLI
0.01
gnomAD missense Z
0.45
DepMap mean gene effect
0.14
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of INHA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INHA as an antibody target. Whether an autoantibody or antibody against INHA could matter depends on whether native INHA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INHA is annotated as secreted, so native INHA circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label INHA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/INHA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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