Intermediate filament head (DNA binding) region

Definition

This family represents the N-terminal head region of intermediate filaments. Intermediate filament heads bind DNA PMID:11513613. Vimentin heads are able to alter nuclear architecture and chromatin distribution, and the liberation of heads by HIV-1 protease liberates may play an important role in HIV-1 associated cytopathogenesis and carcinogenesis PMID:11160829. Phosphorylation of the head region can affect filament stability PMID:12177195. The head has been shown to interaction with the rod domain of the same protein PMID:12064937.

7 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (7 proteins: gene, accession, name)

• DES
• GFAP
• INA
• NEFL
• NEFM
• PRPH
• VIM