IL9R

Protein identityUniProt · HPA

UniProt accession

Q01113

Gene

IL9R

Ensembl

ENSG00000124334

Chromosome

X

Canonical length

521 aa

Protein class

CD markers, Predicted membrane proteins

Secretome location

Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

521 residues, UniProt reviewed canonical sequence.

>Q01113|IL9R
     1  MGLGRCIWEG WTLESEALRR DMGTWLLACI CICTCVCLGV SVTGEGQGPR SRTFTCLTNN
    61  ILRIDCHWSA PELGQGSSPW LLFTSNQAPG GTHKCILRGS ECTVVLPPEA VLVPSDNFTI
   121  TFHHCMSGRE QVSLVDPEYL PRRHVKLDPP SDLQSNISSG HCILTWSISP ALEPMTTLLS
   181  YELAFKKQEE AWEQAQHRDH IVGVTWLILE AFELDPGFIH EARLRVQMAT LEDDVVEEER
   241  YTGQWSEWSQ PVCFQAPQRQ GPLIPPWGWP GNTLVAVSIF LLLTGPTYLL FKLSPRVKRI
   301  FYQNVPSPAM FFQPLYSVHN GNFQTWMGAH GAGVLLSQDC AGTPQGALEP CVQEATALLT
   361  CGPARPWKSV ALEEEQEGPG TRLPGNLSSE DVLPAGCTEW RVQTLAYLPQ EDWAPTSLTR
   421  PAPPDSEGSR SSSSSSSSNN NNYCALGCYG GWHLSALPGN TQSSGPIPAL ACGLSCDHQG
   481  LETQQGVAWV LAGHCQRPGL HEDLQGMLLP SVLSKARSWT F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL9R can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.51

Highest tissue expression

4 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.87

gnomAD pLI

0

gnomAD missense Z

-2.27

DepMap mean gene effect

-0.14

DepMap dependency class

selective

OntologyGO

Biological processes

• immunoglobulin mediated immune response
• interleukin-9-mediated signaling pathway
• regulation of cell population proliferation
• signal transduction

Molecular functions

• interleukin-9 binding
• interleukin-9 receptor activity

Cellular components

• external side of plasma membrane
• extracellular space
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Short hematopoietin receptor, family 1, conserved site
• Fibronectin type III
• Immunoglobulin-like fold
• Fibronectin type III superfamily

KeywordsUniProt

• Cell membrane
• Glycoprotein
• Membrane
• Receptor
• Secreted
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of IL9R in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• IL9
• YWHAZ