IL9

Protein identityUniProt · HPA

UniProt accession

P15248

Gene

IL9

Ensembl

ENSG00000145839

Chromosome

5

Canonical length

144 aa

Protein class

Cancer-related genes, Predicted secreted proteins

Secretome location

Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

144 residues, UniProt reviewed canonical sequence.

>P15248|IL9
     1  MLLAMVLTSA LLLCSVAGQG CPTLAGILDI NFLINKMQED PASKCHCSAN VTSCLCLGIP
    61  SDNCTRPCFS ERLSQMTNTT MQTRYPLIFS RVKKSVEVLK NNKCPYFSCE QPCNQTTAGN
   121  ALTFLKSLLE IFQKEKMRGM RGKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.34

Highest tissue expression

0.9 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for IL9 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.92

gnomAD pLI

0

gnomAD missense Z

0.25

DepMap mean gene effect

0.03

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• B cell differentiation
• B cell proliferation
• immunoglobulin mediated immune response
• inflammatory response
• interleukin-9-mediated signaling pathway
• positive regulation of cell growth
• positive regulation of cell population proliferation
• positive regulation of interleukin-5 production
• regulation of receptor signaling pathway via JAK-STAT

Molecular functions

• cytokine activity
• growth factor activity
• interleukin-9 receptor binding

Cellular components

• extracellular region
• extracellular space

Protein domainsUniProt · Pfam · InterPro

• Interleukin-7/Interleukin-9, conserved site
• Interleukin-9

KeywordsUniProt

• Cytokine
• Glycoprotein
• Growth factor
• Pyrrolidone carboxylic acid
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of IL9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• IL2RG
• IL9R