Seroatlas · Human Serome Atlas

IL2RG

Cytokine receptor common subunit gamma

Also known as: CD132, CIDX, IL2RG_HUMAN, IMD4, SCIDX1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P31785
Gene
IL2RG
Ensembl
ENSG00000147168
Chromosome
X
Canonical length
369 aa
Protein class
Cancer-related genes, CD markers, Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

369 residues, UniProt reviewed canonical sequence.

>P31785|IL2RG
     1  MLKPSLPFTS LLFLQLPLLG VGLNTTILTP NGNEDTTADF FLTTMPTDSL SVSTLPLPEV
    61  QCFVFNVEYM NCTWNSSSEP QPTNLTLHYW YKNSDNDKVQ KCSHYLFSEE ITSGCQLQKK
   121  EIHLYQTFVV QLQDPREPRR QATQMLKLQN LVIPWAPENL TLHKLSESQL ELNWNNRFLN
   181  HCLEHLVQYR TDWDHSWTEQ SVDYRHKFSL PSVDGQKRYT FRVRSRFNPL CGSAQHWSEW
   241  SHPIHWGSNT SKENPFLFAL EAVVISVGSM GLIISLLCVY FWLERTMPRI PTLKNLEDLV
   301  TEYHGNFSAW SGVSKGLAES LQPDYSERLC LVSEIPPKGG ALGEGPGASP CNQHSPYWAP
   361  PCYTLKPET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL2RG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
318 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 318 nTPM
  • tonsil: 283 nTPM
  • lymph node: 217 nTPM
  • appendix: 124 nTPM
  • spleen: 110 nTPM
  • rectum: 109 nTPM

Single-cell type

  • nk-cells: 11 nCPM
  • plasma cells: 9.3 nCPM
  • innate lymphoid cells: 7.7 nCPM
  • neutrophils: 7.4 nCPM
  • t-cells: 6.8 nCPM
  • b-cells: 3.2 nCPM

Immune cell

  • total PBMC: 1,449 nTPM
  • T-reg: 1,387 nTPM
  • memory CD8 T-cell: 1,213 nTPM
  • gdT-cell: 1,177 nTPM
  • NK-cell: 1,164 nTPM
  • MAIT T-cell: 1,152 nTPM

Brain region

  • cerebral cortex: 8.2 nTPM
  • pons: 4.5 nTPM
  • white matter: 3.4 nTPM
  • choroid plexus: 3.2 nTPM
  • medulla oblongata: 3.2 nTPM
  • spinal cord: 2.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IL2RG.

Disease | AllUniProt

Conditions IL2RG is implicated in, by any mechanism.

  • Severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell-negative (XSCID) MIM:300400
  • X-linked combined immunodeficiency (XCID) MIM:312863

Disease | GeneticClinVar

165 pathogenic / likely-pathogenic of 561 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.21
gnomAD pLI
0.99
gnomAD missense Z
1.49
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IL2RG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL2RG as an antibody target. Whether an autoantibody or antibody against IL2RG could matter depends on whether native IL2RG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL2RG is annotated at the cell surface, where native IL2RG is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IL2RG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IL2RG. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...