Seroatlas · Human Serome Atlas

IL10RB

Interleukin-10 receptor subunit beta

Also known as: CDW210B, CRF2-4, CRFB4, D21S58, D21S66, I10R2_HUMAN, IL-10R2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q08334
Gene
IL10RB
Ensembl
ENSG00000243646
Chromosome
21
Canonical length
325 aa
Protein class
CD markers, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

325 residues, UniProt reviewed canonical sequence.

>Q08334|IL10RB
     1  MAWSLGSWLG GCLLVSALGM VPPPENVRMN SVNFKNILQW ESPAFAKGNL TFTAQYLSYR
    61  IFQDKCMNTT LTECDFSSLS KYGDHTLRVR AEFADEHSDW VNITFCPVDD TIIGPPGMQV
   121  EVLADSLHMR FLAPKIENEY ETWTMKNVYN SWTYNVQYWK NGTDEKFQIT PQYDFEVLRN
   181  LEPWTTYCVQ VRGFLPDRNK AGEWSEPVCE QTTHDETVPS WMVAVILMAS VFMVCLALLG
   241  CFALLWCVYK KTKYAFSPRN SLPQHLKEFL GHPHHNTLLF FSFPLSDEND VFDKLSVIAE
   301  DSESGKQNPG DSCSLGTPPG QGPQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL10RB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
55 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 55 nTPM
  • spleen: 41 nTPM
  • small intestine: 41 nTPM
  • colon: 36 nTPM
  • rectum: 34 nTPM
  • duodenum: 32 nTPM

Single-cell type

  • syncytiotrophoblasts: 72 nCPM
  • neutrophils: 72 nCPM
  • colonocytes: 51 nCPM
  • enterocytes: 50 nCPM
  • extravillous trophoblasts: 47 nCPM
  • cytotrophoblasts: 45 nCPM

Immune cell

  • neutrophil: 199 nTPM
  • non-classical monocyte: 113 nTPM
  • intermediate monocyte: 113 nTPM
  • classical monocyte: 102 nTPM
  • basophil: 94 nTPM
  • eosinophil: 86 nTPM

Brain region

  • white matter: 8.1 nTPM
  • thalamus: 7.8 nTPM
  • choroid plexus: 7.1 nTPM
  • medulla oblongata: 6.8 nTPM
  • pons: 6.4 nTPM
  • cerebral cortex: 6.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IL10RB.

Disease | AllUniProt

Conditions IL10RB is implicated in, by any mechanism.

  • Inflammatory bowel disease 25, autosomal recessive (IBD25) MIM:612567

Disease | GeneticClinVar

18 pathogenic / likely-pathogenic of 285 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.12
gnomAD pLI
0
gnomAD missense Z
0.65
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IL10RB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL10RB as an antibody target. Whether an autoantibody or antibody against IL10RB could matter depends on whether native IL10RB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL10RB is annotated at the cell surface, where native IL10RB is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IL10RB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IL10RB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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