Seroatlas · Human Serome Atlas

IL10RA

Interleukin-10 receptor subunit alpha

Also known as: CD210, CD210a, CDW210A, HIL-10R, I10R1_HUMAN, IL10R

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13651
Gene
IL10RA
Ensembl
ENSG00000110324
Chromosome
11
Canonical length
578 aa
Protein class
CD markers, Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane,Primary cilium,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

578 residues, UniProt reviewed canonical sequence.

>Q13651|IL10RA
     1  MLPCLVVLLA ALLSLRLGSD AHGTELPSPP SVWFEAEFFH HILHWTPIPN QSESTCYEVA
    61  LLRYGIESWN SISNCSQTLS YDLTAVTLDL YHSNGYRARV RAVDGSRHSN WTVTNTRFSV
   121  DEVTLTVGSV NLEIHNGFIL GKIQLPRPKM APANDTYESI FSHFREYEIA IRKVPGNFTF
   181  THKKVKHENF SLLTSGEVGE FCVQVKPSVA SRSNKGMWSK EECISLTRQY FTVTNVIIFF
   241  AFVLLLSGAL AYCLALQLYV RRRKKLPSVL LFKKPSPFIF ISQRPSPETQ DTIHPLDEEA
   301  FLKVSPELKN LDLHGSTDSG FGSTKPSLQT EEPQFLLPDP HPQADRTLGN REPPVLGDSC
   361  SSGSSNSTDS GICLQEPSLS PSTGPTWEQQ VGSNSRGQDD SGIDLVQNSE GRAGDTQGGS
   421  ALGHHSPPEP EVPGEEDPAA VAFQGYLRQT RCAEEKATKT GCLEEESPLT DGLGPKFGRC
   481  LVDEAGLHPP ALAKGYLKQD PLEMTLASSG APTGQWNQPT EEWSLLALSS CSDLGISDWS
   541  FAHDLAPLGC VAAPGGLLGS FNSDLVTLPL ISSLQSSE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL10RA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
72 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 72 nTPM
  • bone marrow: 55 nTPM
  • lymph node: 45 nTPM
  • appendix: 33 nTPM
  • tonsil: 28 nTPM
  • small intestine: 24 nTPM

Single-cell type

  • kupffer cells: 342 nCPM
  • monocytes: 233 nCPM
  • neutrophils: 207 nCPM
  • cdc: 187 nCPM
  • macrophages: 166 nCPM
  • extravillous trophoblasts: 162 nCPM

Immune cell

  • T-reg: 85 nTPM
  • total PBMC: 84 nTPM
  • NK-cell: 68 nTPM
  • intermediate monocyte: 66 nTPM
  • memory CD8 T-cell: 60 nTPM
  • non-classical monocyte: 55 nTPM

Brain region

  • medulla oblongata: 4.1 nTPM
  • white matter: 3.8 nTPM
  • spinal cord: 3.1 nTPM
  • hypothalamus: 2.5 nTPM
  • basal ganglia: 1.9 nTPM
  • pons: 1.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IL10RA.

Disease | AllUniProt

Conditions IL10RA is implicated in, by any mechanism.

  • Inflammatory bowel disease 28, autosomal recessive (IBD28) MIM:613148

Disease | GeneticClinVar

22 pathogenic / likely-pathogenic of 497 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Inflammatory bowel disease 28
  • IL10RA-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.69
gnomAD pLI
0.02
gnomAD missense Z
0.64
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IL10RA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL10RA as an antibody target. Whether an autoantibody or antibody against IL10RA could matter depends on whether native IL10RA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL10RA is annotated at the cell surface, where native IL10RA is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IL10RA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IL10RA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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