Seroatlas · Human Serome Atlas

C8orf17

Protein MOST-1

Also known as: MOST1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NRJ1
Gene: C8orf17
Canonical length: 99 aa

OverviewNCBI Gene

No narrative summary is available for C8orf17 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

99 residues, UniProt reviewed canonical sequence.

>Q9NRJ1|C8orf17
     1  MGECPHLVDV RLGHRSLATG PEQSDICHTG SEARWTTTWY GSLSFSRHKY KMLADLTPGV
    61  EMSCRHWARW LTPVIPALWK AEAGGLPELR SSRPAWTTW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C8orf17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -0.22

OntologyGO

Biological processes

Cellular components

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of C8orf17 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C8orf17 as an antibody target. Whether an autoantibody or antibody against C8orf17 could matter depends on whether native C8orf17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C8orf17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C8orf17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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