IGFN1

Protein identityUniProt · HPA

UniProt accession

Q86VF2

Gene

IGFN1

Ensembl

ENSG00000163395

Chromosome

1

Canonical length

1251 aa

Protein class

Predicted intracellular proteins

Subcellular location

Midbody ring

OverviewNCBI Gene

Predicted to act upstream of or within myoblast differentiation and myoblast fusion. Predicted to be located in Z disc and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1251 residues, UniProt reviewed canonical sequence.

>Q86VF2|IGFN1
     1  MAGKLRKSHI PGVSIWQLVE EIPEGCSTPD FEQKPVTSAL PEGKNAVFRA VVCGEPRPEV
    61  RWQNSKGDLS DSSKYKISSS PGSKEHVLQI NKLTGEDTDL YRCTAVNAYG EAACSVRLTV
   121  IEVGFRKNRK RHREPQEDLR KELMDFRKLL KKRAPPAPKK KMDLEQIWQL LMTADRKDYE
   181  KICLKYGIVD YRGMLRRLQE MKKEQEDKMA QYINTISSLR HIRVTKDGNA KFDLELDLKD
   241  SQSKIYLYKD GEMIPYGFNN QTKHCLRRLG KRYEFQIQDL RPEDSGIYQV KVEDAVVFST
   301  ELEASAIPPR VVVPLAETHC EEQGDAVFEC TLSSPCPSAA WHFRHRLLHP SDKYEVYVSP
   361  DGLTHRLVVR GARFSDMGPY SLGTGLYTSS AWLVVEAGKD KDLQSTSADH KLQSRRSGKD
   421  GRLDIYGERR DATRSSTSRY KPGTGSFSKD AQGPMGHFSQ GLADMEVQPG EAATLSCTLT
   481  SDLGPGTWFK DGVKLTTQDG VIFKQDGLVH SLFITHVQGT QAGRYTFVAG DQQSEATLTV
   541  QDSPTIAPDV TEKLREPLVV KAGKPVIVKI PFQSHLPIQA AWRKDGAEVV GSSDREAQVD
   601  LGDGYTRLCL PSAGRKDCGQ YSVTLRSEGG SVQAELTLQV IDKPDPPQGP MEVQDCHRAG
   661  VCLRWRPPRD NGGRTVECYV VERRQAGRST WLKVGEAPAD STTFTDAHVE PGRKYTFRVR
   721  AVTSEGAGEA LESEEILVAP EALPKAPSAP AILSASSQGI TLTWTAPRGP GSAHILGYLI
   781  ERRKKGSNTW TAVNDQPVPE RRWTVADVRQ GCQYEFRVTA VAPSGPGEPG PPSDAVFARD
   841  PMRPPGLVRN LQVTDRSNTS ITLSWAGPDT QEGDEAQGYV VELCSSDSLQ WLPCHVGTVP
   901  VTTYTAKGLR PGEGYFVRVT AVNEGGQSQP SALDTLVQAM PVTVCPKFLV DSSTKDLLTV
   961  KVGDTVRVPV SFEAMPMPEV TWLKDGLPLP KRSVTVTKDG LTQLLIPVAG LSDSGLYTVV
  1021  LRTLQGKEVA HSFRIRVAAC PQAPGPIHLQ ENVPGTVTAE WEPSPDEAQD VPLHYAVFTR
  1081  SSAHGPWHEA ADRIHTNRFT LLGILPGHEY HFRVVAKNEL GASKPSDTSQ PWCIPRQRDR
  1141  FTVKAPCYRE PDLSQKPRFL VGLRSHLLPQ GCECCMSCAV QGSPRPHVTW FKNDRSLEGN
  1201  PAVYSTDLLG VCSLTIPSVS PKDSGEYKAV AENTLGQAVS TATLIVIEPS T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGFN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.34

Highest tissue expression

175 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.94

gnomAD pLI

0

gnomAD missense Z

0.22

DepMap mean gene effect

-0.15

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

• nucleus
• Z disc

Protein domainsUniProt · Pfam · InterPro

• Immunoglobulin subtype 2
• Immunoglobulin domain subtype
• Fibronectin type III
• Immunoglobulin-like domain
• Immunoglobulin I-set
• Immunoglobulin-like fold
• Fibronectin type III superfamily
• Immunoglobulin-like domain superfamily
• MyBP-C, tri-helix bundle domain
• Striated Muscle Structural and Regulatory Protein
• Fibronectin type III domain
• Immunoglobulin I-set domain
• Tri-helix bundle domain

KeywordsUniProt

• Coiled coil
• Cytoplasm
• Immunoglobulin domain
• Nucleus
• Repeat

InteractionsUniProt · HPA

Protein binding partners of IGFN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FLNC
• KY