Ketoreductase domain

Definition

The ketoreductase (KR) domain is a conserved catalytic domain that belongs to the short-chain dehydrogenase/reductase (SDR) superfamily and contains a Rossmann fold, which is crucial for binding the NADPH cofactor PMID:26863427. Its primary function is to catalyse the NADPH-dependent reduction of beta-keto groups to beta-hydroxy groups during the biosynthesis of fatty acids, polyketides, and related compounds. The specific substrates and products can vary depending on the enzyme [[cite:PMID:27118242], [cite:PMID:18723688]]. The ketoreductase (KR) domain is a conserved catalytic domain in various enzyme systems involved in fatty acid and polyketide biosynthesis. It is present in: Mammalian fatty acid synthases (FAS) Polyketide synthases (PKS) Fungal 6-methylsalicylic acid synthase Bacterial phthioceranic/hydroxyphthioceranic acid synthases 3-oxoacyl-[acyl-carrier-protein] reductase FabG Diacetyl reductase [(S)-acetoin forming] Acetoacetyl-CoA reductase Hydroxynaphthalene reductase-like protein Arp2

6 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (6 proteins: gene, accession, name)

• CBR4
• DECR2
• DHRS3
• FASN
• HSD17B4
• HSD17B8