Seroatlas · Human Serome Atlas

HJURP

Holliday junction recognition protein

Also known as: DKFZp762E1312, FAKTS, hFLEG1, HJURP_HUMAN, URLC9

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NCD3
Gene: HJURP
Ensembl: ENSG00000123485
Chromosome: 2
Canonical length: 748 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Enables histone binding activity and identical protein binding activity. Involved in CENP-A containing chromatin assembly; chromosome segregation; and regulation of protein-containing complex assembly. Located in cytosol; kinetochore; and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

748 residues, UniProt reviewed canonical sequence.

>Q8NCD3|HJURP
     1  MLGTLRAMEG EDVEDDQLLQ KLRASRRRFQ RRMQRLIEKY NQPFEDTPVV QMATLTYETP
    61  QGLRIWGGRL IKERNEGEIQ DSSMKPADRT DGSVQAAAWG PELPSHRTVL GADSKSGEVD
   121  ATSDQEESVA WALAPAVPQS PLKNELRRKY LTQVDILLQG AEYFECAGNR AGRDVRVTPL
   181  PSLASPAVPA PGYCSRISRK SPGDPAKPAS SPREWDPLHP SSTDMALVPR NDSLSLQETS
   241  SSSFLSSQPF EDDDICNVTI SDLYAGMLHS MSRLLSTKPS SIISTKTFIM QNWNSRRRHR
   301  YKSRMNKTYC KGARRSQRSS KENFIPCSEP VKGTGALRDC KNVLDVSCRK TGLKLEKAFL
   361  EVNRPQIHKL DPSWKERKVT PSKYSSLIYF DSSATYNLDE ENRFRTLKWL ISPVKIVSRP
   421  TIRQGHGENR QREIEIRFDQ LHREYCLSPR NQPRRMCLPD SWAMNMYRGG PASPGGLQGL
   481  ETRRLSLPSS KAKAKSLSEA FENLGKRSLE AGRCLPKSDS SSSLPKTNPT HSATRPQQTS
   541  DLHVQGNSSG IFRKSVSPSK TLSVPDKEVP GHGRNRYDEI KEEFDKLHQK YCLKSPGQMT
   601  VPLCIGVSTD KASMEVRYQT EGFLGKLNPD PHFQGFQKLP SSPLGCRKSL LGSTAIEAPS
   661  STCVARAITR DGTRDHQFPA KRPRLSEPQG SGRQGNSLGA SDGVDNTVRP GDQGSSSQPN
   721  SEERGENTSY RMEEKSDFML EKLETKSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HJURP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 45 nTPM
thymus: 28 nTPM
lymph node: 12 nTPM
tonsil: 11 nTPM
testis: 10 nTPM
esophagus: 5.3 nTPM

Single-cell type

oocytes: 97 nCPM
monocyte progenitors: 66 nCPM
late primary spermatocytes: 59 nCPM
erythrocyte progenitors: 53 nCPM
megakaryocyte progenitors: 36 nCPM
differentiating spermatogonia: 27 nCPM

Immune cell

T-reg: 1.2 nTPM
non-classical monocyte: 0.4 nTPM
total PBMC: 0.4 nTPM
basophil: 0.2 nTPM
neutrophil: 0.2 nTPM
memory CD4 T-cell: 0.1 nTPM

Brain region

thalamus: 1.8 nTPM
pons: 1.5 nTPM
cerebral cortex: 1.4 nTPM
white matter: 1.4 nTPM
medulla oblongata: 1.3 nTPM
choroid plexus: 1.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HJURP.

Disease | ImmuneIEDB

Conditions an epitope on HJURP was assayed in.

female reproductive organ cancer T cell
cervical cancer T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.79
gnomAD pLI: 0
gnomAD missense Z: -0.3
DepMap mean gene effect: -0.96
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Holliday junction regulator protein family C-terminal
Holliday junction regulator protein family C-terminal repeat
Centromere protein Scm3/HJURP
Holliday junction recognition protein, HJURP, central domain
Centromere protein Scm3
Holliday junction recognition protein-associated repeat

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HJURP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HJURP as an antibody target. Whether an autoantibody or antibody against HJURP could matter depends on whether native HJURP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HJURP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HJURP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...