Seroatlas · Human Serome Atlas

CD300H

Protein CD300H

Also known as: CD3CH_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A0K2S4Q6
Gene: CD300H
Ensembl: ENSG00000284690
Chromosome: 17
Canonical length: 201 aa
Protein class: Predicted membrane proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene belongs to the CD300 gene family, which in turn, belongs to the immunoglobulin (Ig) superfamily. This gene is located within a CD300 cluster on chromosome 17. The encoded protein may be involved in innate immunity as well as autoimmune response. A G>A mutation, represented by the single nucleotide polymorphism (SNP) rs905709, at the splice donor site of the 5' terminal exon may be associated with lack of expression of this gene in homozygous (AA) individuals. The human reference assembly (GRCh38.p2) represents the 'A' allele at this SNP. [provided by RefSeq, Apr 2016]

Canonical amino-acid sequenceUniProt

201 residues, UniProt reviewed canonical sequence.

>A0A0K2S4Q6|CD300H
     1  MTQRAGAAML PSALLLLCVP GCLTVSGPST VMGAVGESLS VQCRYEEKYK TFNKYWCRQP
    61  CLPIWHEMVE TGGSEGVVRS DQVIITDHPG DLTFTVTLEN LTADDAGKYR CGIATILQED
   121  GLSGFLPDPF FQVQVLVSSA SSTENSVKTP ASPTRPSQCQ GSLPSSTCFL LLPLLKVPLL
   181  LSILGAILWV NRPWRTPWTE S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD300H can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 7.3 nTPM

Expression across tissuesHPA

Tissue

spleen: 7.3 nTPM
appendix: 3.9 nTPM
bone marrow: 3.4 nTPM
adipose tissue: 2.1 nTPM
choroid plexus: 2.1 nTPM
lung: 2 nTPM

Single-cell type

monocytes: 4.5 nCPM
cdc: 3.7 nCPM
neutrophils: 2.3 nCPM
macrophages: 1.2 nCPM
hofbauer cells: 0.1 nCPM
rod photoreceptor cells: 0.1 nCPM

Immune cell

non-classical monocyte: 1,136 nTPM
intermediate monocyte: 655 nTPM
myeloid DC: 95 nTPM
total PBMC: 92 nTPM
neutrophil: 79 nTPM
classical monocyte: 78 nTPM

Brain region

thalamus: 4.8 nTPM
cerebral cortex: 4.4 nTPM
choroid plexus: 1.8 nTPM
white matter: 1.1 nTPM
hypothalamus: 0.9 nTPM
pons: 0.9 nTPM

OntologyGO

Biological processes

Molecular functions

transmembrane signaling receptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CD300H in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD300H as an antibody target. Whether an autoantibody or antibody against CD300H could matter depends on whether native CD300H is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD300H is annotated as secreted, so native CD300H circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

The encoded protein may be involved in innate immunity as well as autoimmune response.

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