Seroatlas · Human Serome Atlas

CD5L

CD5 antigen-like

Also known as: API6, CD5L_HUMAN, Spalpha

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43866
Gene: CD5L
Ensembl: ENSG00000073754
Chromosome: 1
Canonical length: 347 aa
Protein class: Plasma proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

Predicted to be involved in cellular defense response. Predicted to act upstream of or within positive regulation of complement-dependent cytotoxicity and regulation of complement activation. Located in cell surface. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

347 residues, UniProt reviewed canonical sequence.

>O43866|CD5L
     1  MALLFSLILA ICTRPGFLAS PSGVRLVGGL HRCEGRVEVE QKGQWGTVCD DGWDIKDVAV
    61  LCRELGCGAA SGTPSGILYE PPAEKEQKVL IQSVSCTGTE DTLAQCEQEE VYDCSHDEDA
   121  GASCENPESS FSPVPEGVRL ADGPGHCKGR VEVKHQNQWY TVCQTGWSLR AAKVVCRQLG
   181  CGRAVLTQKR CNKHAYGRKP IWLSQMSCSG REATLQDCPS GPWGKNTCNH DEDTWVECED
   241  PFDLRLVGGD NLCSGRLEVL HKGVWGSVCD DNWGEKEDQV VCKQLGCGKS LSPSFRDRKC
   301  YGPGVGRIWL DNVRCSGEEQ SLEQCQHRFW GFHDCTHQED VAVICSG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD5L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 540 nTPM

Expression across tissuesHPA

Tissue

spleen: 540 nTPM
liver: 98 nTPM
bone marrow: 16 nTPM
lymph node: 8.6 nTPM
thymus: 5.7 nTPM
placenta: 2 nTPM

Single-cell type

kupffer cells: 1,539 nCPM
hofbauer cells: 634 nCPM
macrophages: 153 nCPM
platelets: 34 nCPM
cardiomyocytes: 6.2 nCPM
erythrocytes: 4.7 nCPM

Immune cell

non-classical monocyte: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 0.6 nTPM
choroid plexus: 0.4 nTPM
medulla oblongata: 0.4 nTPM
hypothalamus: 0.3 nTPM
pons: 0.3 nTPM
white matter: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.67
gnomAD pLI: 0
gnomAD missense Z: 0.06
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

apoptotic process
cellular defense response
immune system process
inflammatory response
positive regulation of phagocytosis, engulfment
regulation of complement activation
response to wounding
positive regulation of complement-dependent cytotoxicity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CD5L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD5L as an antibody target. Whether an autoantibody or antibody against CD5L could matter depends on whether native CD5L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD5L is annotated as secreted, so native CD5L circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CD5L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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