Seroatlas · Human Serome Atlas

HMGN4

High mobility group nucleosome-binding domain-containing protein 4

Also known as: HMG17L3, HMGN4_HUMAN, NHC

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O00479
Gene: HMGN4
Ensembl: ENSG00000182952
Chromosome: 6
Canonical length: 90 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

The protein encoded by this gene, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. [provided by RefSeq, Mar 2013]

Canonical amino-acid sequenceUniProt

90 residues, UniProt reviewed canonical sequence.

>O00479|HMGN4
     1  MPKRKAKGDA KGDKAKVKDE PQRRSARLSA KPAPPKPEPR PKKASAKKGE KLPKGRKGKA
    61  DAGKDGNNPA KNRDASTLQS QKAEGTGDAK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HMGN4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.74
Highest tissue expression: 67 nTPM

Expression across tissuesHPA

Tissue

tonsil: 67 nTPM
thymus: 66 nTPM
lymph node: 64 nTPM
smooth muscle: 62 nTPM
parathyroid gland: 55 nTPM
blood vessel: 55 nTPM

Single-cell type

extravillous trophoblasts: 154 nCPM
megakaryocytes: 142 nCPM
decidual stromal cells: 114 nCPM
syncytiotrophoblasts: 113 nCPM
migrating cytotrophoblasts: 102 nCPM
melanocytes: 93 nCPM

Immune cell

basophil: 182 nTPM
T-reg: 94 nTPM
total PBMC: 92 nTPM
memory CD8 T-cell: 86 nTPM
memory CD4 T-cell: 85 nTPM
eosinophil: 82 nTPM

Brain region

choroid plexus: 40 nTPM
hypothalamus: 27 nTPM
white matter: 26 nTPM
midbrain: 24 nTPM
spinal cord: 24 nTPM
medulla oblongata: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.86
gnomAD pLI: 0.32
gnomAD missense Z: 0.27
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

chromatin organization

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HMGN4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HMGN4 as an antibody target. Whether an autoantibody or antibody against HMGN4 could matter depends on whether native HMGN4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HMGN4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HMGN4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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