GSTM3

Protein identityUniProt · HPA

UniProt accession

P21266

Gene

GSTM3

Ensembl

ENSG00000134202

Chromosome

1

Canonical length

225 aa

Protein class

Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Microtubules,Cytokinetic bridge,Primary cilium,Primary cilium tip,Primary cilium transition zone,Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

Canonical amino-acid sequenceUniProt

225 residues, UniProt reviewed canonical sequence.

>P21266|GSTM3
     1  MSCESSMVLG YWDIRGLAHA IRLLLEFTDT SYEEKRYTCG EAPDYDRSQW LDVKFKLDLD
    61  FPNLPYLLDG KNKITQSNAI LRYIARKHNM CGETEEEKIR VDIIENQVMD FRTQLIRLCY
   121  SSDHEKLKPQ YLEELPGQLK QFSMFLGKFS WFAGEKLTFV DFLTYDILDQ NRIFDPKCLD
   181  EFPNLKAFMC RFEALEKIAA YLQSDQFCKM PINNKMAQWG NKPVC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GSTM3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

93 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.17

gnomAD pLI

0

gnomAD missense Z

0.94

DepMap mean gene effect

-0.23

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular detoxification of nitrogen compound
• establishment of blood-nerve barrier
• glutathione metabolic process
• nitrobenzene metabolic process
• response to estrogen
• xenobiotic catabolic process

Molecular functions

• enzyme binding
• glutathione binding
• glutathione transferase activity
• identical protein binding
• protein homodimerization activity

Cellular components

• cytoplasm
• cytosol
• extracellular exosome
• nucleus
• sperm fibrous sheath

Protein domainsUniProt · Pfam · InterPro

• Glutathione S-transferase, Mu class
• Glutathione S-transferase, N-terminal
• Glutathione S-transferase, C-terminal
• Glutathione S-transferase, C-terminal-like
• Thioredoxin-like superfamily
• Glutathione S-transferase, C-terminal domain superfamily
• Glutathione transferase family
• Glutathione S-transferase superfamily
• Glutathione S-transferase, C-terminal domain
• Glutathione S-transferase, N-terminal domain

KeywordsUniProt

• Cytoplasm
• Isopeptide bond
• Transferase
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of GSTM3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• GSTM4
• GSTM5