Seroatlas · Human Serome Atlas

RAMP3

Receptor activity-modifying protein 3

Also known as: RAMP3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O60896
Gene
RAMP3
Ensembl
ENSG00000122679
Chromosome
7
Canonical length
148 aa
Protein class
FDA approved drug targets, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

148 residues, UniProt reviewed canonical sequence.

>O60896|RAMP3
     1  METGALRRPQ LLPLLLLLCG GCPRAGGCNE TGMLERLPLC GKAFADMMGK VDVWKWCNLS
    61  EFIVYYESFT NCTEMEANVV GCYWPNPLAQ GFITGIHRQF FSNCTVDRVH LEDPPDEVLI
   121  PLIVIPVVLT VAMAGLVVWR SKRTDTLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAMP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
138 nTPM

Expression across tissuesHPA

Tissue

  • lung: 138 nTPM
  • spinal cord: 111 nTPM
  • heart muscle: 91 nTPM
  • adipose tissue: 84 nTPM
  • kidney: 83 nTPM
  • thyroid gland: 70 nTPM

Single-cell type

  • vascular endothelial cells: 410 nCPM
  • lymphatic endothelial cells: 185 nCPM
  • podocytes: 87 nCPM
  • hepatic stellate cells: 52 nCPM
  • decidual stromal cells: 30 nCPM
  • early spermatids: 25 nCPM

Immune cell

  • neutrophil: 0.6 nTPM
  • total PBMC: 0.3 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • white matter: 62 nTPM
  • medulla oblongata: 55 nTPM
  • pons: 48 nTPM
  • spinal cord: 42 nTPM
  • cerebellum: 32 nTPM
  • hypothalamus: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.57
gnomAD pLI
0.02
gnomAD missense Z
0.56
DepMap mean gene effect
0.13
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAMP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAMP3 as an antibody target. Whether an autoantibody or antibody against RAMP3 could matter depends on whether native RAMP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAMP3 is annotated at the cell surface, where native RAMP3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RAMP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RAMP3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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