Seroatlas · Human Serome Atlas

SLC35D3

Solute carrier family 35 member D3

Also known as: FRCL1, S35D3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5M8T2
Gene: SLC35D3
Ensembl: ENSG00000182747
Chromosome: 6
Canonical length: 416 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Centriolar satellite

OverviewNCBI Gene

Enables UDP-glucose transmembrane transporter activity. Involved in UDP-glucose transmembrane transport. Is active in synaptic vesicle membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

416 residues, UniProt reviewed canonical sequence.

>Q5M8T2|SLC35D3
     1  MRQLCRGRVL GISVAIAHGV FSGSLNILLK FLISRYQFSF LTLVQCLTSS TAALSLELLR
    61  RLGLIAVPPF GLSLARSFAG VAVLSTLQSS LTLWSLRGLS LPMYVVFKRC LPLVTMLIGV
   121  LVLKNGAPSP GVLAAVLITT CGAALAGAGD LTGDPIGYVT GVLAVLVHAA YLVLIQKASA
   181  DTEHGPLTAQ YVIAVSATPL LVICSFASTD SIHAWTFPGW KDPAMVCIFV ACILIGCAMN
   241  FTTLHCTYIN SAVTTSFVGV VKSIATITVG MVAFSDVEPT SLFIAGVVVN TLGSIIYCVA
   301  KFMETRKQSN YEDLEAQPRG EEAQLSGDQL PFVMEELPGE GGNGRSEGGE AAGGPAQESR
   361  QEVRGSPRGV PLVAGSSEEG SRRSLKDAYL EVWRLVRGTR YMKKDYLIEN EELPSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC35D3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 10
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 5.7 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 5.7 nTPM
hypothalamus: 3 nTPM
midbrain: 1.2 nTPM
adrenal gland: 0.9 nTPM
stomach: 0.5 nTPM
colon: 0.4 nTPM

Single-cell type

megakaryocytes: 50 nCPM
platelets: 18 nCPM
other brain neurons: 4.8 nCPM
pancreatic islet cells: 3.1 nCPM
brain inhibitory neurons: 2.5 nCPM
megakaryocyte progenitors: 2.4 nCPM

Immune cell

total PBMC: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

hypothalamus: 13 nTPM
thalamus: 12 nTPM
basal ganglia: 7.9 nTPM
midbrain: 4.7 nTPM
medulla oblongata: 1.2 nTPM
amygdala: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0.04
gnomAD missense Z: 1.07
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Triose Phosphate/Phosphate Translocator

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC35D3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

GPCPD1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC35D3 as an antibody target. Whether an autoantibody or antibody against SLC35D3 could matter depends on whether native SLC35D3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC35D3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC35D3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...