Seroatlas · Human Serome Atlas

GPC2

Glypican-2

Also known as: cerebroglycan, DKFZp547M109, FLJ38962, GPC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N158
Gene
GPC2
Ensembl
ENSG00000213420
Chromosome
7
Canonical length
579 aa
Protein class
Predicted intracellular proteins
Secretome location
Intracellular and membrane

OverviewNCBI Gene

Predicted to be involved in several processes, including positive regulation of neuron projection development; regulation of protein localization to membrane; and smoothened signaling pathway. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

579 residues, UniProt reviewed canonical sequence.

>Q8N158|GPC2
     1  MSALRPLLLL LLPLCPGPGP GPGSEAKVTR SCAETRQVLG ARGYSLNLIP PALISGEHLR
    61  VCPQEYTCCS SETEQRLIRE TEATFRGLVE DSGSFLVHTL AARHRKFDEF FLEMLSVAQH
   121  SLTQLFSHSY GRLYAQHALI FNGLFSRLRD FYGESGEGLD DTLADFWAQL LERVFPLLHP
   181  QYSFPPDYLL CLSRLASSTD GSLQPFGDSP RRLRLQITRT LVAARAFVQG LETGRNVVSE
   241  ALKVPVSEGC SQALMRLIGC PLCRGVPSLM PCQGFCLNVV RGCLSSRGLE PDWGNYLDGL
   301  LILADKLQGP FSFELTAESI GVKISEGLMY LQENSAKVSA QVFQECGPPD PVPARNRRAP
   361  PPREEAGRLW SMVTEEERPT TAAGTNLHRL VWELRERLAR MRGFWARLSL TVCGDSRMAA
   421  DASLEAAPCW TGAGRGRYLP PVVGGSPAEQ VNNPELKVDA SGPDVPTRRR RLQLRAATAR
   481  MKTAALGHDL DGQDADEDAS GSGGGQQYAD DWMAGAVAPP ARPPRPPYPP RRDGSGGKGG
   541  GGSARYNQGR SRSGGASIGF HTQTILILSL SALALLGPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • testis: 11 nTPM
  • skin: 5.5 nTPM
  • thymus: 4.8 nTPM
  • amygdala: 2.2 nTPM
  • spinal cord: 2.1 nTPM
  • hippocampal formation: 2 nTPM

Single-cell type

  • early spermatids: 42 nCPM
  • oligodendrocyte progenitor cells: 18 nCPM
  • late primary spermatocytes: 14 nCPM
  • early primary spermatocytes: 11 nCPM
  • thymocytes: 9.3 nCPM
  • differentiating spermatogonia: 8.6 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 2.2 nTPM
  • medulla oblongata: 1.6 nTPM
  • spinal cord: 1.5 nTPM
  • cerebral cortex: 1.4 nTPM
  • hippocampal formation: 1.4 nTPM
  • amygdala: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.56
gnomAD pLI
0.03
gnomAD missense Z
1.01
DepMap mean gene effect
-0.19
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPC2 as an antibody target. Whether an autoantibody or antibody against GPC2 could matter depends on whether native GPC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPC2 is annotated at the cell surface, where native GPC2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GPC2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...