Seroatlas · Human Serome Atlas

GOLGA7

Golgin subfamily A member 7

Also known as: GCP16, GOGA7_HUMAN, GOLGA3AP1, GOLGA7A, HSPC041

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z5G4
Gene: GOLGA7
Ensembl: ENSG00000147533
Chromosome: 8
Canonical length: 137 aa
Protein class: Predicted intracellular proteins, Transporters

OverviewNCBI Gene

Involved in Golgi to plasma membrane protein transport; peptidyl-L-cysteine S-palmitoylation; and protein stabilization. Acts upstream of or within Golgi to plasma membrane transport. Located in Golgi membrane and Golgi stack. Part of palmitoyltransferase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

137 residues, UniProt reviewed canonical sequence.

>Q7Z5G4|GOLGA7
     1  MRPQQAPVSG KVFIQRDYSS GTRCQFQTKF PAELENRIDR QQFEETVRTL NNLYAEAEKL
    61  GGQSYLEGCL ACLTAYTIFL CMETHYEKVL KKVSKYIQEQ NEKIYAPQGL LLTDPIERGL
   121  RVIEITIYED RGMSSGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLGA7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 104 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 104 nTPM
midbrain: 93 nTPM
amygdala: 82 nTPM
hippocampal formation: 82 nTPM
basal ganglia: 81 nTPM
hypothalamus: 58 nTPM

Single-cell type

oocytes: 304 nCPM
neutrophils: 296 nCPM
early primary spermatocytes: 188 nCPM
differentiating spermatogonia: 139 nCPM
esophageal apical cells: 122 nCPM
syncytiotrophoblasts: 113 nCPM

Immune cell

basophil: 285 nTPM
total PBMC: 201 nTPM
neutrophil: 190 nTPM
T-reg: 144 nTPM
gdT-cell: 120 nTPM
classical monocyte: 120 nTPM

Brain region

white matter: 181 nTPM
basal ganglia: 151 nTPM
medulla oblongata: 129 nTPM
midbrain: 123 nTPM
cerebral cortex: 118 nTPM
thalamus: 115 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.63
gnomAD pLI: 0.46
gnomAD missense Z: 1.45
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GOLGA7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOLGA7 as an antibody target. Whether an autoantibody or antibody against GOLGA7 could matter depends on whether native GOLGA7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOLGA7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOLGA7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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