Seroatlas · Human Serome Atlas

ZDHHC9

Palmitoyltransferase ZDHHC9

Also known as: CGI-89, CXorf11, DHHC9, ZDHC9_HUMAN, ZDHHC10, ZNF379, ZNF380

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y397
Gene: ZDHHC9
Ensembl: ENSG00000188706
Chromosome: X
Canonical length: 364 aa
Protein class: Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location: Endoplasmic reticulum,Golgi apparatus,Cytosol

OverviewNCBI Gene

This gene encodes an integral membrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein forms a complex with golgin subfamily A member 7 and functions as a palmitoyltransferase. This protein specifically palmitoylates HRAS and NRAS. Mutations in this gene are associated with X-linked cognitive disability. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

364 residues, UniProt reviewed canonical sequence.

>Q9Y397|ZDHHC9
     1  MSVMVVRKKV TRKWEKLPGR NTFCCDGRVM MARQKGIFYL TLFLILGTCT LFFAFECRYL
    61  AVQLSPAIPV FAAMLFLFSM ATLLRTSFSD PGVIPRALPD EAAFIEMEIE ATNGAVPQGQ
   121  RPPPRIKNFQ INNQIVKLKY CYTCKIFRPP RASHCSICDN CVERFDHHCP WVGNCVGKRN
   181  YRYFYLFILS LSLLTIYVFA FNIVYVALKS LKIGFLETLK ETPGTVLEVL ICFFTLWSVV
   241  GLTGFHTFLV ALNQTTNEDI KGSWTGKNRV QNPYSHGNIV KNCCEVLCGP LPPSVLDRRG
   301  ILPLEESGSR PPSTQETSSS LLPQSPAPTE HLNSNEMPED SSTPEEMPPP EPPEPPQEAA
   361  EAEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZDHHC9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 53 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 53 nTPM
cerebral cortex: 39 nTPM
liver: 38 nTPM
hippocampal formation: 37 nTPM
kidney: 35 nTPM
skin: 33 nTPM

Single-cell type

pituicytes/fscs: 224 nCPM
alveolar cells type 1: 217 nCPM
oligodendrocytes: 173 nCPM
alveolar cells type 2: 156 nCPM
transitional alveolar cells: 130 nCPM
endometrial luminal cells: 106 nCPM

Immune cell

non-classical monocyte: 5.2 nTPM
plasmacytoid DC: 5.2 nTPM
naive CD4 T-cell: 4.5 nTPM
MAIT T-cell: 3.7 nTPM
memory CD4 T-cell: 3.6 nTPM
gdT-cell: 3 nTPM

Brain region

white matter: 137 nTPM
basal ganglia: 116 nTPM
cerebral cortex: 106 nTPM
medulla oblongata: 106 nTPM
midbrain: 100 nTPM
thalamus: 99 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZDHHC9.

Disease | AllUniProt

Conditions ZDHHC9 is implicated in, by any mechanism.

Intellectual developmental disorder, X-linked, syndromic, Raymond type (MRXSR) MIM:300799

Disease | GeneticClinVar

21 pathogenic / likely-pathogenic of 377 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Syndromic X-linked intellectual disability Raymond type
Inborn genetic diseases
Intellectual disability
Thyroid cancer, nonmedullary, 1

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.48
gnomAD pLI: 0.74
gnomAD missense Z: 2.55
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

palmitoyltransferase activity
protein-cysteine S-palmitoyltransferase activity
Ras palmitoyltransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZDHHC9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

GOLGA7

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZDHHC9 as an antibody target. Whether an autoantibody or antibody against ZDHHC9 could matter depends on whether native ZDHHC9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZDHHC9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZDHHC9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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