Seroatlas · Human Serome Atlas

CLDND1

Claudin domain-containing protein 1

Also known as: C3orf4, CLDN1_HUMAN, Z38

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NY35
Gene: CLDND1
Ensembl: ENSG00000080822
Chromosome: 3
Canonical length: 253 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Located in cell surface. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

253 residues, UniProt reviewed canonical sequence.

>Q9NY35|CLDND1
     1  MDNRFATAFV IACVLSLIST IYMAASIGTD FWYEYRSPVQ ENSSDLNKSI WDEFISDEAD
    61  EKTYNDALFR YNGTVGLWRR CITIPKNMHW YSPPERTESF DVVTKCVSFT LTEQFMEKFV
   121  DPGNHNSGID LLRTYLWRCQ FLLPFVSLGL MCFGALIGLC ACICRSLYPT IATGILHLLA
   181  GLCTLGSVSC YVAGIELLHQ KLELPDNVSG EFGWSFCLAC VSAPLQFMAS ALFIWAAHTN
   241  RKEYTLMKAY RVA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLDND1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 1,440 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 1,440 nTPM
midbrain: 714 nTPM
hippocampal formation: 483 nTPM
basal ganglia: 350 nTPM
amygdala: 342 nTPM
hypothalamus: 312 nTPM

Single-cell type

esophageal apical cells: 693 nCPM
oligodendrocytes: 682 nCPM
late primary spermatocytes: 268 nCPM
extravillous trophoblasts: 235 nCPM
late spermatids: 174 nCPM
suprabasal keratinocytes: 152 nCPM

Immune cell

T-reg: 401 nTPM
NK-cell: 275 nTPM
MAIT T-cell: 194 nTPM
memory CD4 T-cell: 191 nTPM
memory CD8 T-cell: 187 nTPM
basophil: 181 nTPM

Brain region

white matter: 1,634 nTPM
medulla oblongata: 1,199 nTPM
basal ganglia: 976 nTPM
cerebellum: 871 nTPM
pons: 864 nTPM
midbrain: 813 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.62
gnomAD pLI: 0.16
gnomAD missense Z: 0.09
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CLDND1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

GOLGA7

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLDND1 as an antibody target. Whether an autoantibody or antibody against CLDND1 could matter depends on whether native CLDND1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLDND1 is annotated at the cell surface, where native CLDND1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CLDND1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...