Seroatlas · Human Serome Atlas

TAS2R14

Taste receptor type 2 member 14

Also known as: T2R14, T2R14_HUMAN, TRB1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NYV8
Gene
TAS2R14
Ensembl
ENSG00000212127
Chromosome
12
Canonical length
317 aa
Protein class
G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

317 residues, UniProt reviewed canonical sequence.

>Q9NYV8|TAS2R14
     1  MGGVIKSIFT FVLIVEFIIG NLGNSFIALV NCIDWVKGRK ISSVDRILTA LAISRISLVW
    61  LIFGSWCVSV FFPALFATEK MFRMLTNIWT VINHFSVWLA TGLGTFYFLK IANFSNSIFL
   121  YLKWRVKKVV LVLLLVTSVF LFLNIALINI HINASINGYR RNKTCSSDSS NFTRFSSLIV
   181  LTSTVFIFIP FTLSLAMFLL LIFSMWKHRK KMQHTVKISG DASTKAHRGV KSVITFFLLY
   241  AIFSLSFFIS VWTSERLEEN LIILSQVMGM AYPSCHSCVL ILGNKKLRQA SLSVLLWLRY
   301  MFKDGEPSGH KEFRESS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAS2R14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
5.2 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 5.2 nTPM
  • ovary: 3.1 nTPM
  • pituitary gland: 2.8 nTPM
  • endometrium: 2.3 nTPM
  • epididymis: 2.3 nTPM
  • thyroid gland: 2.3 nTPM

Single-cell type

  • bergmann glia: 1.5 nCPM
  • innate lymphoid cells: 1.2 nCPM
  • oligodendrocyte progenitor cells: 1.1 nCPM
  • oligodendrocytes: 1.1 nCPM
  • brain excitatory neurons: 0.8 nCPM
  • other brain neurons: 0.7 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 1.4 nTPM
  • medulla oblongata: 1.3 nTPM
  • amygdala: 1 nTPM
  • hippocampal formation: 0.9 nTPM
  • midbrain: 0.6 nTPM
  • pons: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z
-0.12
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TAS2R14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAS2R14 as an antibody target. Whether an autoantibody or antibody against TAS2R14 could matter depends on whether native TAS2R14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAS2R14 is annotated at the cell surface, where native TAS2R14 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TAS2R14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TAS2R14. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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