GLO1
Lactoylglutathione lyase
Also known as: GLOD1, LGUL_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q04760
- Gene
- GLO1
- Ensembl
- ENSG00000124767
- Chromosome
- 6
- Canonical length
- 184 aa
- Protein class
- Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Plasma membrane,Cytosol
- Quaternary structure
- Homodimer
OverviewNCBI Gene
The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
184 residues, UniProt reviewed canonical sequence.
>Q04760|GLO1
1 MAEPQPPSGG LTDEAALSCC SDADPSTKDF LLQQTMLRVK DPKKSLDFYT RVLGMTLIQK
61 CDFPIMKFSL YFLAYEDKND IPKEKDEKIA WALSRKATLE LTHNWGTEDD ETQSYHNGNS
121 DPRGFGHIGI AVPDVYSACK RFEELGVKFV KKPDDGKMKG LAFIQDPDGY WIEILNPNKM
181 ATLMLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GLO1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.36
- Highest tissue expression
- 161 nTPM
Expression across tissuesHPA
Tissue
- prostate: 161 nTPM
- liver: 148 nTPM
- skeletal muscle: 144 nTPM
- tongue: 120 nTPM
- duodenum: 109 nTPM
- epididymis: 105 nTPM
Single-cell type
- extravillous trophoblasts: 424 nCPM
- kupffer cells: 249 nCPM
- esophageal apical cells: 244 nCPM
- migrating cytotrophoblasts: 233 nCPM
- esophageal suprabasal cells: 213 nCPM
- urothelial cells: 202 nCPM
Immune cell
- plasmacytoid DC: 61 nTPM
- memory B-cell: 52 nTPM
- naive B-cell: 52 nTPM
- MAIT T-cell: 48 nTPM
- myeloid DC: 39 nTPM
- memory CD8 T-cell: 37 nTPM
Brain region
- spinal cord: 67 nTPM
- choroid plexus: 66 nTPM
- white matter: 65 nTPM
- hypothalamus: 63 nTPM
- medulla oblongata: 62 nTPM
- pons: 60 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.46
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.42
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- carbohydrate metabolic process
- glutathione metabolic process
- methylglyoxal metabolic process
- negative regulation of apoptotic process
- osteoclast differentiation
- regulation of transcription by RNA polymerase II
Molecular functions
- zinc ion binding
- lactoylglutathione lyase activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GLO1 as an antibody target. Whether an autoantibody or antibody against GLO1 could matter depends on whether native GLO1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GLO1 is annotated at the cell surface, where native GLO1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label GLO1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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