Seroatlas · Human Serome Atlas

GDF10

Growth/differentiation factor 10

Also known as: BMP-3b, GDF10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P55107
Gene
GDF10
Ensembl
ENSG00000266524
Chromosome
10
Canonical length
478 aa
Protein class
Plasma proteins, Predicted secreted proteins
Subcellular location
Vesicles
Secretome location
Secreted in other tissues
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This promotes neural repair after stroke. Additionally, this protein may act as a tumor suppressor and reduced expression of this gene is associated with oral cancer. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

478 residues, UniProt reviewed canonical sequence.

>P55107|GDF10
     1  MAHVPARTSP GPGPQLLLLL LPLFLLLLRD VAGSHRAPAW SALPAAADGL QGDRDLQRHP
    61  GDAAATLGPS AQDMVAVHMH RLYEKYSRQG ARPGGGNTVR SFRARLEVVD QKAVYFFNLT
   121  SMQDSEMILT ATFHFYSEPP RWPRALEVLC KPRAKNASGR PLPLGPPTRQ HLLFRSLSQN
   181  TATQGLLRGA MALAPPPRGL WQAKDISPIV KAARRDGELL LSAQLDSEER DPGVPRPSPY
   241  APYILVYAND LAISEPNSVA VTLQRYDPFP AGDPEPRAAP NNSADPRVRR AAQATGPLQD
   301  NELPGLDERP PRAHAQHFHK HQLWPSPFRA LKPRPGRKDR RKKGQEVFMA ASQVLDFDEK
   361  TMQKARRKQW DEPRVCSRRY LKVDFADIGW NEWIISPKSF DAYYCAGACE FPMPKIVRPS
   421  NHATIQSIVR AVGIIPGIPE PCCVPDKMNS LGVLFLDENR NVVLKVYPNM SVDTCACR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GDF10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • lung: 17 nTPM
  • retina: 17 nTPM
  • pancreas: 12 nTPM
  • adipose tissue: 11 nTPM
  • blood vessel: 9.9 nTPM
  • tongue: 9.7 nTPM

Single-cell type

  • adrenal medulla cells: 53 nCPM
  • bergmann glia: 45 nCPM
  • rod photoreceptor cells: 22 nCPM
  • fibroblasts: 22 nCPM
  • schwann cells: 20 nCPM
  • retinal bipolar cells: 14 nCPM

Immune cell

  • naive CD4 T-cell: 0.2 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • midbrain: 13 nTPM
  • hippocampal formation: 13 nTPM
  • basal ganglia: 12 nTPM
  • thalamus: 12 nTPM
  • amygdala: 12 nTPM
  • cerebellum: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.84
gnomAD pLI
0.01
gnomAD missense Z
0.59
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GDF10 as an antibody target. Whether an autoantibody or antibody against GDF10 could matter depends on whether native GDF10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GDF10 is annotated as secreted, so native GDF10 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label GDF10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GDF10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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