Seroatlas · Human Serome Atlas

GAS2

Growth arrest-specific protein 2

Also known as: GAS2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43903
Gene
GAS2
Ensembl
ENSG00000148935
Chromosome
11
Canonical length
313 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2017]

Canonical amino-acid sequenceUniProt

313 residues, UniProt reviewed canonical sequence.

>O43903|GAS2
     1  MCTALSPKVR SGPGLSDMHQ YSQWLASRHE ANLLPMKEDL ALWLTNLLGK EITAETFMEK
    61  LDNGALLCQL AETMQEKFKE SMDANKPTKN LPLKKIPCKT SAPSGSFFAR DNTANFLSWC
   121  RDLGVDETCL FESEGLVLHK QPREVCLCLL ELGRIAARYG VEPPGLIKLE KEIEQEETLS
   181  APSPSPSPSS KSSGKKSTGN LLDDAVKRIS EDPPCKCPNK FCVERLSQGR YRVGEKILFI
   241  RMLHNKHVMV RVGGGWETFA GYLLKHDPCR MLQISRVDGK TSPIQSKSPT LKDMNPDNYL
   301  VVSASYKAKK EIK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GAS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
37 nTPM

Expression across tissuesHPA

Tissue

  • liver: 37 nTPM
  • spinal cord: 10 nTPM
  • pancreas: 9.2 nTPM
  • thymus: 7.7 nTPM
  • kidney: 5 nTPM
  • midbrain: 4.2 nTPM

Single-cell type

  • myonuclei: 745 nCPM
  • gonadotrophs: 461 nCPM
  • hepatocytes: 291 nCPM
  • cardiomyocytes: 227 nCPM
  • retinal ganglion cells: 174 nCPM
  • lactotrophs: 127 nCPM

Immune cell

  • MAIT T-cell: 0.2 nTPM
  • naive CD4 T-cell: 0.2 nTPM
  • memory B-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • midbrain: 24 nTPM
  • medulla oblongata: 21 nTPM
  • pons: 21 nTPM
  • thalamus: 21 nTPM
  • white matter: 21 nTPM
  • cerebral cortex: 20 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GAS2.

Disease | AllUniProt

Conditions GAS2 is implicated in, by any mechanism.

  • Deafness, autosomal recessive, 125 (DFNB125) MIM:620877

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 42 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Hearing loss, autosomal recessive 125

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.81
gnomAD pLI
0
gnomAD missense Z
0.44
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GAS2 as an antibody target. Whether an autoantibody or antibody against GAS2 could matter depends on whether native GAS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GAS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GAS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GAS2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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