Seroatlas · Human Serome Atlas

GABRA6

Gamma-aminobutyric acid receptor subunit alpha-6

Also known as: GBRA6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q16445
Gene
GABRA6
Ensembl
ENSG00000145863
Chromosome
5
Canonical length
453 aa
Protein class
FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

453 residues, UniProt reviewed canonical sequence.

>Q16445|GABRA6
     1  MASSLPWLCI ILWLENALGK LEVEGNFYSE NVSRILDNLL EGYDNRLRPG FGGAVTEVKT
    61  DIYVTSFGPV SDVEMEYTMD VFFRQTWTDE RLKFGGPTEI LSLNNLMVSK IWTPDTFFRN
   121  GKKSIAHNMT TPNKLFRIMQ NGTILYTMRL TINADCPMRL VNFPMDGHAC PLKFGSYAYP
   181  KSEIIYTWKK GPLYSVEVPE ESSSLLQYDL IGQTVSSETI KSNTGEYVIM TVYFHLQRKM
   241  GYFMIQIYTP CIMTVILSQV SFWINKESVP ARTVFGITTV LTMTTLSISA RHSLPKVSYA
   301  TAMDWFIAVC FAFVFSALIE FAAVNYFTNL QTQKAKRKAQ FAAPPTVTIS KATEPLEAEI
   361  VLHPDSKYHL KKRITSLSLP IVSSSEANKV LTRAPILQST PVTPPPLSPA FGGTSKIDQY
   421  SRILFPVAFA GFNLVYWVVY LSKDTMEVSS SVE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GABRA6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
186 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 186 nTPM
  • spinal cord: 2.7 nTPM
  • basal ganglia: 0.7 nTPM
  • choroid plexus: 0.7 nTPM
  • cerebral cortex: 0.5 nTPM
  • testis: 0.5 nTPM

Single-cell type

  • brain excitatory neurons: 88 nCPM
  • epicardial cells: 27 nCPM
  • brain inhibitory neurons: 26 nCPM
  • sertoli cells: 24 nCPM
  • other brain neurons: 6.6 nCPM
  • bergmann glia: 4.9 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 150 nTPM
  • pons: 11 nTPM
  • cerebral cortex: 6.1 nTPM
  • white matter: 5 nTPM
  • midbrain: 3.2 nTPM
  • spinal cord: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.38
gnomAD pLI
0
gnomAD missense Z
-0.41
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GABRA6 as an antibody target. Whether an autoantibody or antibody against GABRA6 could matter depends on whether native GABRA6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GABRA6 is annotated at the cell surface, where native GABRA6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GABRA6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GABRA6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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