Gamma-aminobutyric acid receptor subunit alpha 1-6, transmembrane domain

Definition

This entry represents the transmembrane domain (TM) of the six alpha subunits of Gamma-aminobutyric acid receptor (Gabra-1-6). A decline in the function of this complex, which acts as an anionic channel that mediates fast inhibitory synaptic transmission, triggers hyperactive neurological disorders such as insomnia, anxiety, and epilepsy [[cite:PMID:29053855], [cite:PMID:27388150]]. This domain consists of four transmembrane-spanning α-helical segments that are linked by loops. The intracellular loop that links the first two α-helical segments determines the ion selectivity of the channel PMID:28967882.

6 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (6 proteins: gene, accession, name)

• GABRA1
• GABRA2
• GABRA3
• GABRA4
• GABRA5
• GABRA6