Seroatlas · Human Serome Atlas

GABRA3

Gamma-aminobutyric acid receptor subunit alpha-3

Also known as: GBRA3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P34903
Gene
GABRA3
Ensembl
ENSG00000011677
Chromosome
X
Canonical length
492 aa
Protein class
FDA approved drug targets, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Plasma membrane

OverviewNCBI Gene

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

492 residues, UniProt reviewed canonical sequence.

>P34903|GABRA3
     1  MIITQTSHCY MTSLGILFLI NILPGTTGQG ESRRQEPGDF VKQDIGGLSP KHAPDIPDDS
    61  TDNITIFTRI LDRLLDGYDN RLRPGLGDAV TEVKTDIYVT SFGPVSDTDM EYTIDVFFRQ
   121  TWHDERLKFD GPMKILPLNN LLASKIWTPD TFFHNGKKSV AHNMTTPNKL LRLVDNGTLL
   181  YTMRLTIHAE CPMHLEDFPM DVHACPLKFG SYAYTTAEVV YSWTLGKNKS VEVAQDGSRL
   241  NQYDLLGHVV GTEIIRSSTG EYVVMTTHFH LKRKIGYFVI QTYLPCIMTV ILSQVSFWLN
   301  RESVPARTVF GVTTVLTMTT LSISARNSLP KVAYATAMDW FIAVCYAFVF SALIEFATVN
   361  YFTKRSWAWE GKKVPEALEM KKKTPAAPAK KTSTTFNIVG TTYPINLAKD TEFSTISKGA
   421  APSASSTPTI IASPKATYVQ DSPTETKTYN SVSKVDKISR IIFPVLFAIF NLVYWATYVN
   481  RESAIKGMIR KQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GABRA3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
32 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 32 nTPM
  • cerebral cortex: 16 nTPM
  • hypothalamus: 14 nTPM
  • hippocampal formation: 8.7 nTPM
  • retina: 8.3 nTPM
  • amygdala: 6.8 nTPM

Single-cell type

  • choroid plexus epithelial cells: 224 nCPM
  • hofbauer cells: 98 nCPM
  • oligodendrocyte progenitor cells: 74 nCPM
  • other brain neurons: 62 nCPM
  • retinal amacrine cells: 57 nCPM
  • brain excitatory neurons: 55 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 52 nTPM
  • hypothalamus: 49 nTPM
  • cerebral cortex: 44 nTPM
  • basal ganglia: 42 nTPM
  • hippocampal formation: 29 nTPM
  • midbrain: 23 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GABRA3.

Disease | AllUniProt

Conditions GABRA3 is implicated in, by any mechanism.

  • Epilepsy, X-linked 2, with or without impaired intellectual development and dysmorphic features (EPILX2) MIM:301091

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 108 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Epilepsy, X-linked 2, with or without impaired intellectual development and dysmorphic features
  • Inborn genetic diseases

Disease | ImmuneIEDB

Conditions an epitope on GABRA3 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.7
gnomAD pLI
0.04
gnomAD missense Z
2.53
DepMap mean gene effect
0.25
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GABRA3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GABRA3 as an antibody target. Whether an autoantibody or antibody against GABRA3 could matter depends on whether native GABRA3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GABRA3 is annotated at the cell surface, where native GABRA3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GABRA3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GABRA3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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