Seroatlas · Human Serome Atlas

FRMD6

FERM domain-containing protein 6

Also known as: C14orf31, EX1, FRMD6_HUMAN, MGC17921, willin

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96NE9
Gene: FRMD6
Ensembl: ENSG00000139926
Chromosome: 14
Canonical length: 622 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to be involved in positive regulation of hippo signaling. Predicted to act upstream of or within apical constriction; protein localization; and regulation of actin filament-based process. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

622 residues, UniProt reviewed canonical sequence.

>Q96NE9|FRMD6
     1  MNKLNFHNNR VMQDRRSVCI FLPNDESLNI IINVKILCHQ LLVQVCDLLR LKDCHLFGLS
    61  VIQNNEHVYM ELSQKLYKYC PKEWKKEASK VRQYEVTWGI DQFGPPMIIH FRVQYYVENG
   121  RLISDRAARY YYYWHLRKQV LHSQCVLREE AYFLLAAFAL QADLGNFKRN KHYGKYFEPE
   181  AYFPSWVVSK RGKDYILKHI PNMHKDQFAL TASEAHLKYI KEAVRLDDVA VHYYRLYKDK
   241  REIEASLTLG LTMRGIQIFQ NLDEEKQLLY DFPWTNVGKL VFVGKKFEIL PDGLPSARKL
   301  IYYTGCPMRS RHLLQLLSNS HRLYMNLQPV LRHIRKLEEN EEKKQYRESY ISDNLDLDMD
   361  QLEKRSRASG SSAGSMKHKR LSRHSTASHS SSHTSGIEAD TKPRDTGPED SYSSSAIHRK
   421  LKTCSSMTSH GSSHTSGVES GGKDRLEEDL QDDEIEMLVD DPRDLEQMNE ESLEVSPDMC
   481  IYITEDMLMS RKLNGHSGLI VKEIGSSTSS SSETVVKLRG QSTDSLPQTI CRKPKTSTDR
   541  HSLSLDDIRL YQKDFLRIAG LCQDTAQSYT FGCGHELDEE GLYCNSCLAQ QCINIQDAFP
   601  VKRTSKYFSL DLTHDEVPEF VV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FRMD6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 57 nTPM

Expression across tissuesHPA

Tissue

esophagus: 57 nTPM
skin: 57 nTPM
endometrium: 53 nTPM
smooth muscle: 44 nTPM
gallbladder: 35 nTPM
testis: 32 nTPM

Single-cell type

late spermatids: 769 nCPM
suprabasal keratinocytes: 604 nCPM
esophageal apical cells: 569 nCPM
esophageal suprabasal cells: 538 nCPM
basal keratinocytes: 453 nCPM
urothelial cells: 431 nCPM

Immune cell

basophil: 0.9 nTPM
naive CD4 T-cell: 0.8 nTPM
naive CD8 T-cell: 0.6 nTPM
gdT-cell: 0.2 nTPM
memory CD4 T-cell: 0.2 nTPM
classical monocyte: 0.1 nTPM

Brain region

cerebellum: 71 nTPM
amygdala: 70 nTPM
thalamus: 68 nTPM
basal ganglia: 60 nTPM
midbrain: 57 nTPM
cerebral cortex: 56 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.5
gnomAD pLI: 0.03
gnomAD missense Z: 0.26
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

FERM domain
PH-like domain superfamily
FERM/acyl-CoA-binding protein superfamily
FERM, N-terminal
FERM, C-terminal PH-like domain
FERM central domain
Band 4.1 domain
Ubiquitin-like domain superfamily
FERM superfamily, second domain
FERM domain-containing protein 6-like
FERM central domain
FERM N-terminal domain
FERM C-terminal PH-like domain
FERM domain-containing protein 6, FERM domain C-lobe

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FRMD6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FRMD6 as an antibody target. Whether an autoantibody or antibody against FRMD6 could matter depends on whether native FRMD6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FRMD6 is annotated at the cell surface, where native FRMD6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FRMD6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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