Seroatlas · Human Serome Atlas

S1PR4

Sphingosine 1-phosphate receptor 4

Also known as: EDG6, S1PR4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95977
Gene
S1PR4
Ensembl
ENSG00000125910
Chromosome
19
Canonical length
384 aa
Protein class
G-protein coupled receptors, Predicted membrane proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

This gene is a member of the endothelial differentiation, G-protein-coupled (EDG)) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

384 residues, UniProt reviewed canonical sequence.

>O95977|S1PR4
     1  MNATGTPVAP ESCQQLAAGG HSRLIVLHYN HSGRLAGRGG PEDGGLGALR GLSVAASCLV
    61  VLENLLVLAA ITSHMRSRRW VYYCLVNITL SDLLTGAAYL ANVLLSGART FRLAPAQWFL
   121  REGLLFTALA ASTFSLLFTA GERFATMVRP VAESGATKTS RVYGFIGLCW LLAALLGMLP
   181  LLGWNCLCAF DRCSSLLPLY SKRYILFCLV IFAGVLATIM GLYGAIFRLV QASGQKAPRP
   241  AARRKARRLL KTVLMILLAF LVCWGPLFGL LLADVFGSNL WAQEYLRGMD WILALAVLNS
   301  AVNPIIYSFR SREVCRAVLS FLCCGCLRLG MRGPGDCLAR AVEAHSGAST TDSSLRPRDS
   361  FRGSRSLSFR MREPLSSISS VRSI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against S1PR4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
59 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 59 nTPM
  • bone marrow: 19 nTPM
  • lymph node: 16 nTPM
  • small intestine: 13 nTPM
  • lung: 11 nTPM
  • appendix: 10 nTPM

Single-cell type

  • neutrophils: 291 nCPM
  • neutrophil progenitors: 89 nCPM
  • nk-cells: 58 nCPM
  • t-cells: 50 nCPM
  • megakaryocyte-erythroid progenitors: 47 nCPM
  • hematopoietic stem cells: 44 nCPM

Immune cell

  • neutrophil: 121 nTPM
  • eosinophil: 81 nTPM
  • T-reg: 68 nTPM
  • basophil: 54 nTPM
  • non-classical monocyte: 45 nTPM
  • naive B-cell: 40 nTPM

Brain region

  • cerebral cortex: 5.6 nTPM
  • pons: 1.7 nTPM
  • thalamus: 1.6 nTPM
  • amygdala: 1.2 nTPM
  • medulla oblongata: 1.1 nTPM
  • basal ganglia: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.3
gnomAD pLI
0
gnomAD missense Z
0.08
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of S1PR4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads S1PR4 as an antibody target. Whether an autoantibody or antibody against S1PR4 could matter depends on whether native S1PR4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

S1PR4 is annotated at the cell surface, where native S1PR4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label S1PR4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/S1PR4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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