Seroatlas · Human Serome Atlas

FOXRED2

FAD-dependent oxidoreductase domain-containing protein 2

Also known as: ERFAD, FLJ23322, FXRD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IWF2
Gene: FOXRED2
Ensembl: ENSG00000100350
Chromosome: 22
Canonical length: 684 aa
Protein class: Predicted intracellular proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Enables flavin adenine dinucleotide binding activity. Involved in ERAD pathway. Located in endoplasmic reticulum lumen. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

684 residues, UniProt reviewed canonical sequence.

>Q8IWF2|FOXRED2
     1  MGLSAAAPLW GPPGLLLAIA LHPALSVPPR RDYCVLGAGP AGLQMAYFLQ RAGRDYAVFE
    61  RAPRPGSFFT RYPRHRKLIS INKRYTGKAN AEFNLRHDWN SLLSHDPRLL FRHYSRAYFP
   121  DARDMVRYLG DFADTLGLRV QYNTTIAHVT LDKDRQAWNG HYFILTDQKG QVHQCSVLFV
   181  ATGLSVPNQV DFPGSEYAEG YESVSVDPED FVGQNVLILG RGNSAFETAE NILGVTNFIH
   241  MLSRSRVRLS WATHYVGDLR AINNGLLDTY QLKSLDGLLE SDLTDLAILK DSKGKFHVTP
   301  KFFLEEANTN QSADSITLPQ DDNDNFAMRV PYDRVIRCLG WNFDFSIFNK SLRLNSGNAF
   361  GKKYPLIRAS YESKGSRGLF ILGTASHSVD YRKSAGGFIH GFRYTVRAVH RLLEHRHHSV
   421  TWPATELPIT QLTSSIVRRV NEASGLYQMF GVLADVILLK ENSTAFEYLE EFPIQMLAQL
   481  ETLTGRKAKH GLFVINMEYG RNFSGPDKDV FFDDRSVGHT EDAWQSNFLH PVIYYYRYLP
   541  TEQEVRFRPA HWPLPRPTAI HHIVEDFLTD WTAPIGHILP LRRFLENCLD TDLRSFYAES
   601  CFLFALTRQK LPPFCQQGYL RMQGLVSTES LWQHRVESRL LRDYAPTGRR LEDSSQQLGD
   661  QEPLGSPLAP GPLAQSVDSN KEEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FOXRED2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 14 nTPM
amygdala: 13 nTPM
ovary: 9.8 nTPM
epididymis: 9.4 nTPM
basal ganglia: 9.3 nTPM
hippocampal formation: 9 nTPM

Single-cell type

retinal pigment epithelial cells: 51 nCPM
kupffer cells: 34 nCPM
differentiating spermatogonia: 34 nCPM
hofbauer cells: 21 nCPM
early primary spermatocytes: 20 nCPM
cytotrophoblasts: 17 nCPM

Immune cell

plasmacytoid DC: 5.3 nTPM
intermediate monocyte: 1 nTPM
MAIT T-cell: 0.9 nTPM
classical monocyte: 0.8 nTPM
myeloid DC: 0.7 nTPM
non-classical monocyte: 0.6 nTPM

Brain region

cerebral cortex: 40 nTPM
basal ganglia: 36 nTPM
amygdala: 35 nTPM
white matter: 31 nTPM
midbrain: 30 nTPM
thalamus: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.62
gnomAD pLI: 0
gnomAD missense Z: 0.68
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

ERAD pathway

Molecular functions

Cellular components

endoplasmic reticulum lumen

Protein domainsUniProt · Pfam · InterPro

FAD/NAD(P)-binding domain superfamily
Auxin biosynthesis and cation transport
Pyridine nucleotide-disulphide oxidoreductase

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FOXRED2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FOXRED2 as an antibody target. Whether an autoantibody or antibody against FOXRED2 could matter depends on whether native FOXRED2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FOXRED2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FOXRED2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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