Seroatlas · Human Serome Atlas

FLVCR1

Choline/ethanolamine transporter FLVCR1

Also known as: AXPC1, FLVC1_HUMAN, FLVCR, MFSD7B, PCA, SLC49A1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y5Y0
Gene
FLVCR1
Ensembl
ENSG00000162769
Chromosome
1
Canonical length
555 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Cell Junctions

OverviewNCBI Gene

This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein is a heme transporter that may play a critical role in erythropoiesis by protecting developing erythroid cells from heme toxicity. This gene may play a role in posterior column ataxia with retinitis pigmentosa and the hematological disorder Diamond-Blackfan syndrome. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

555 residues, UniProt reviewed canonical sequence.

>Q9Y5Y0|FLVCR1
     1  MARPDDEEGA AVAPGHPLAK GYLPLPRGAP VGKESVELQN GPKAGTFPVN GAPRDSLAAA
    61  SGVLGGPQTP LAPEEETQAR LLPAGAGAET PGAESSPLPL TALSPRRFVV LLIFSLYSLV
   121  NAFQWIQYSI ISNVFEGFYG VTLLHIDWLS MVYMLAYVPL IFPATWLLDT RGLRLTALLG
   181  SGLNCLGAWI KCGSVQQHLF WVTMLGQCLC SVAQVFILGL PSRIASVWFG PKEVSTACAT
   241  AVLGNQLGTA VGFLLPPVLV PNTQNDTNLL ACNISTMFYG TSAVATLLFI LTAIAFKEKP
   301  RYPPSQAQAA LQDSPPEEYS YKKSIRNLFK NIPFVLLLIT YGIMTGAFYS VSTLLNQMIL
   361  TYYEGEEVNA GRIGLTLVVA GMVGSILCGL WLDYTKTYKQ TTLIVYILSF IGMVIFTFTL
   421  DLRYIIIVFV TGGVLGFFMT GYLPLGFEFA VEITYPESEG TSSGLLNASA QIFGILFTLA
   481  QGKLTSDYGP KAGNIFLCVW MFIGIILTAL IKSDLRRHNI NIGITNVDVK AIPADSPTDQ
   541  EPKTVMLSKQ SESAI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FLVCR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • small intestine: 18 nTPM
  • duodenum: 9.1 nTPM
  • pituitary gland: 6.6 nTPM
  • retina: 6.3 nTPM
  • cerebellum: 6.1 nTPM
  • bone marrow: 5.8 nTPM

Single-cell type

  • neutrophil progenitors: 148 nCPM
  • gonadotrophs: 124 nCPM
  • enterocytes: 114 nCPM
  • neuroendocrine cells: 81 nCPM
  • adrenal medulla cells: 75 nCPM
  • mucous neck cells: 72 nCPM

Immune cell

  • eosinophil: 1.5 nTPM
  • neutrophil: 0.7 nTPM
  • basophil: 0.4 nTPM
  • plasmacytoid DC: 0.4 nTPM
  • T-reg: 0.4 nTPM
  • memory CD4 T-cell: 0.3 nTPM

Brain region

  • pons: 16 nTPM
  • cerebellum: 15 nTPM
  • hypothalamus: 14 nTPM
  • medulla oblongata: 14 nTPM
  • midbrain: 13 nTPM
  • white matter: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FLVCR1.

Disease | AllUniProt

Conditions FLVCR1 is implicated in, by any mechanism.

  • Retinopathy-sensory neuropathy syndrome (RETSNS) MIM:609033
  • Neurodevelopmental disorder with microcephaly, absent speech, and hypotonia (NEDMISH) MIM:621060

Disease | GeneticClinVar

59 pathogenic / likely-pathogenic of 606 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.67
gnomAD pLI
0
gnomAD missense Z
0.85
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FLVCR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FLVCR1 as an antibody target. Whether an autoantibody or antibody against FLVCR1 could matter depends on whether native FLVCR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FLVCR1 is annotated at the cell surface, where native FLVCR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FLVCR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FLVCR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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