HPX

Protein identityUniProt · HPA

UniProt accession

P02790

Gene

HPX

Ensembl

ENSG00000110169

Chromosome

11

Canonical length

462 aa

Protein class

Candidate cardiovascular disease genes, Plasma proteins, Predicted secreted proteins

Secretome location

Secreted to blood

OverviewNCBI Gene

This gene encodes a plasma glycoprotein that binds heme with high affinity. The encoded protein is an acute phase protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative stress. [provided by RefSeq, Apr 2009]

Canonical amino-acid sequenceUniProt

462 residues, UniProt reviewed canonical sequence.

>P02790|HPX
     1  MARVLGAPVA LGLWSLCWSL AIATPLPPTS AHGNVAEGET KPDPDVTERC SDGWSFDATT
    61  LDDNGTMLFF KGEFVWKSHK WDRELISERW KNFPSPVDAA FRQGHNSVFL IKGDKVWVYP
   121  PEKKEKGYPK LLQDEFPGIP SPLDAAVECH RGECQAEGVL FFQGDREWFW DLATGTMKER
   181  SWPAVGNCSS ALRWLGRYYC FQGNQFLRFD PVRGEVPPRY PRDVRDYFMP CPGRGHGHRN
   241  GTGHGNSTHH GPEYMRCSPH LVLSALTSDN HGATYAFSGT HYWRLDTSRD GWHSWPIAHQ
   301  WPQGPSAVDA AFSWEEKLYL VQGTQVYVFL TKGGYTLVSG YPKRLEKEVG TPHGIILDSV
   361  DAAFICPGSS RLHIMAGRRL WWLDLKSGAQ ATWTELPWPH EKVDGALCME KSLGPNSCSA
   421  NGPGLYLIHG PNLYCYSDVE KLNAAKALPQ PQNVTSLLGC TH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HPX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.29

Highest tissue expression

4,943 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HPX.

Disease | ImmuneIEDB

Conditions an epitope on HPX was assayed in.

• rheumatoid arthritis B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.13

gnomAD pLI

0

gnomAD missense Z

0.82

DepMap mean gene effect

0.02

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• heme metabolic process
• heme transport
• hemoglobin metabolic process
• intracellular iron ion homeostasis
• positive regulation of humoral immune response mediated by circulating immunoglobulin
• positive regulation of immunoglobulin production
• positive regulation of type II interferon-mediated signaling pathway
• regulation of protein metabolic process
• type II interferon-mediated signaling pathway

Molecular functions

• heme transmembrane transporter activity
• metal ion binding

Cellular components

• blood microparticle
• endocytic vesicle lumen
• extracellular exosome
• extracellular matrix
• extracellular region
• extracellular space

Protein domainsUniProt · Pfam · InterPro

• Hemopexin-like domain
• Hemopexin, conserved site
• Hemopexin-like repeats
• Hemopexin-like domain superfamily
• Heme transport and cell adhesion protein
• Hemopexin
• Hemopexin

KeywordsUniProt

• Disulfide bond
• Glycoprotein
• Heme
• Host-virus interaction
• Iron
• Metal-binding
• Repeat
• Secreted
• Signal
• Transport

InteractionsUniProt · HPA

Protein binding partners of HPX in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FLVCR1