Seroatlas · Human Serome Atlas

FGA

Fibrinogen alpha chain

Also known as: FIBA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P02671
Gene: FGA
Ensembl: ENSG00000171560
Chromosome: 4
Canonical length: 866 aa
Protein class: Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted secreted proteins
Subcellular location: Endoplasmic reticulum
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, the encoded preproprotein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

866 residues, UniProt reviewed canonical sequence.

>P02671|FGA
     1  MFSMRIVCLV LSVVGTAWTA DSGEGDFLAE GGGVRGPRVV ERHQSACKDS DWPFCSDEDW
    61  NYKCPSGCRM KGLIDEVNQD FTNRINKLKN SLFEYQKNNK DSHSLTTNIM EILRGDFSSA
   121  NNRDNTYNRV SEDLRSRIEV LKRKVIEKVQ HIQLLQKNVR AQLVDMKRLE VDIDIKIRSC
   181  RGSCSRALAR EVDLKDYEDQ QKQLEQVIAK DLLPSRDRQH LPLIKMKPVP DLVPGNFKSQ
   241  LQKVPPEWKA LTDMPQMRME LERPGGNEIT RGGSTSYGTG SETESPRNPS SAGSWNSGSS
   301  GPGSTGNRNP GSSGTGGTAT WKPGSSGPGS TGSWNSGSSG TGSTGNQNPG SPRPGSTGTW
   361  NPGSSERGSA GHWTSESSVS GSTGQWHSES GSFRPDSPGS GNARPNNPDW GTFEEVSGNV
   421  SPGTRREYHT EKLVTSKGDK ELRTGKEKVT SGSTTTTRRS CSKTVTKTVI GPDGHKEVTK
   481  EVVTSEDGSD CPEAMDLGTL SGIGTLDGFR HRHPDEAAFF DTASTGKTFP GFFSPMLGEF
   541  VSETESRGSE SGIFTNTKES SSHHPGIAEF PSRGKSSSYS KQFTSSTSYN RGDSTFESKS
   601  YKMADEAGSE ADHEGTHSTK RGHAKSRPVR DCDDVLQTHP SGTQSGIFNI KLPGSSKIFS
   661  VYCDQETSLG GWLLIQQRMD GSLNFNRTWQ DYKRGFGSLN DEGEGEFWLG NDYLHLLTQR
   721  GSVLRVELED WAGNEAYAEY HFRVGSEAEG YALQVSSYEG TAGDALIEGS VEEGAEYTSH
   781  NNMQFSTFDR DADQWEENCA EVYGGGWWYN NCQAANLNGI YYPGGSYDPR NNSPYEIENG
   841  VVWVSFRGAD YSLRAVRMKI RPLVTQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FGA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 17,202 nTPM

Expression across tissuesHPA

Tissue

liver: 17,202 nTPM
stomach: 45 nTPM
kidney: 19 nTPM
pancreas: 17 nTPM
gallbladder: 13 nTPM
spleen: 8.2 nTPM

Single-cell type

hepatocytes: 17,124 nCPM
cholangiocytes: 388 nCPM
fallopian tube ciliated cells: 272 nCPM
kupffer cells: 207 nCPM
parietal cells: 92 nCPM
late spermatids: 86 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FGA.

Disease | AllUniProt

Conditions FGA is implicated in, by any mechanism.

Congenital afibrinogenemia (CAFBN) MIM:202400
Amyloidosis, hereditary systemic 2 (AMYLD2) MIM:105200
Dysfibrinogenemia, congenital (DYSFIBRIN) MIM:616004

Disease | GeneticClinVar

58 pathogenic / likely-pathogenic of 355 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Familial dysfibrinogenemia
Congenital afibrinogenemia
Familial visceral amyloidosis, Ostertag type
FGA-related disorder
Hypofibrinogenemia

Disease | ImmuneIEDB

Conditions an epitope on FGA was assayed in.

rheumatoid arthritis B and T cell
musculoskeletal system disease B cell
systemic lupus erythematosus B cell
psoriatic arthritis B cell
pancreatic ductal adenocarcinoma T cell
reactive arthritis B cell
ankylosing spondylitis B cell
osteoarthritis B cell
rheumatic disease B cell
myocardial infarction T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0
gnomAD missense Z: -0.67
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FGA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FGA as an antibody target. Whether an autoantibody or antibody against FGA could matter depends on whether native FGA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FGA is annotated as secreted, so native FGA circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FGA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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