IL22RA1

Protein identityUniProt · HPA

UniProt accession

Q8N6P7

Gene

IL22RA1

Ensembl

ENSG00000142677

Chromosome

1

Canonical length

574 aa

Protein class

Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

574 residues, UniProt reviewed canonical sequence.

>Q8N6P7|IL22RA1
     1  MRTLLTILTV GSLAAHAPED PSDLLQHVKF QSSNFENILT WDSGPEGTPD TVYSIEYKTY
    61  GERDWVAKKG CQRITRKSCN LTVETGNLTE LYYARVTAVS AGGRSATKMT DRFSSLQHTT
   121  LKPPDVTCIS KVRSIQMIVH PTPTPIRAGD GHRLTLEDIF HDLFYHLELQ VNRTYQMHLG
   181  GKQREYEFFG LTPDTEFLGT IMICVPTWAK ESAPYMCRVK TLPDRTWTYS FSGAFLFSMG
   241  FLVAVLCYLS YRYVTKPPAP PNSLNVQRVL TFQPLRFIQE HVLIPVFDLS GPSSLAQPVQ
   301  YSQIRVSGPR EPAGAPQRHS LSEITYLGQP DISILQPSNV PPPQILSPLS YAPNAAPEVG
   361  PPSYAPQVTP EAQFPFYAPQ AISKVQPSSY APQATPDSWP PSYGVCMEGS GKDSPTGTLS
   421  SPKHLRPKGQ LQKEPPAGSC MLGGLSLQEV TSLAMEESQE AKSLHQPLGI CTDRTSDPNV
   481  LHSGEEGTPQ YLKGQLPLLS SVQIEGHPMS LPLQPPSRPC SPSDQGPSPW GLLESLVCPK
   541  DEAKSPAPET SDLEQPTELD SLFRGLALTV QWES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL22RA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.56

Highest tissue expression

189 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.63

gnomAD pLI

0.01

gnomAD missense Z

0.18

DepMap mean gene effect

-0.15

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cytokine-mediated signaling pathway
• defense response to Gram-negative bacterium
• negative regulation of cytokine production involved in inflammatory response
• negative regulation of inflammatory response

Molecular functions

• cytokine receptor activity
• interleukin-20 binding
• interleukin-22 receptor activity
• interferon receptor activity

Cellular components

• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Fibronectin type III
• Immunoglobulin-like fold
• Fibronectin type III superfamily
• Tissue factor

KeywordsUniProt

• Cell membrane
• Disulfide bond
• Glycoprotein
• Membrane
• Phosphoprotein
• Receptor
• Repeat
• Signal
• Transmembrane
• Transmembrane helix
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of IL22RA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FBXW12
• IL22
• STAT3