FBXO30

Protein identityUniProt · HPA

UniProt accession

Q8TB52

Gene

FBXO30

Ensembl

ENSG00000118496

Chromosome

6

Canonical length

745 aa

Protein class

Predicted intracellular proteins

Subcellular location

Microtubules

OverviewNCBI Gene

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it is upregulated in nasopharyngeal carcinoma. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

745 residues, UniProt reviewed canonical sequence.

>Q8TB52|FBXO30
     1  MEEELQHSHC VNCVSRRCMT RPEPGISCDL IGCPLVCGAV FHSCKADEHR LLCPFERVPC
    61  LNSDFGCPFT MARNKVAEHL EMCPASVVCC TMEWNRWPVS YADRKSYENL SRDVDEVAQL
   121  DMALALQDQR MLLESLKVAT MMSKATDKVS KPREQISVKS SVPEIPHANG LVSVDEESYG
   181  ALYQATVETT RSLAAALDIL NTATRDIGML NTSVPNDMDE QQNARESLED QNLKDQDHLY
   241  EEEIGAVGGI DYNDTNQNAQ SEQNGSSDLL CDLNTSSYDT SALCNGFPLE NICTQVIDQN
   301  QNLHGDSKQS NLTNGDCVAS SDGTSKPSSS LAVAAQLREI IPSSALPNGT VQHILMPDDE
   361  GEGELCWKKV DLGDVKNVDV LSFSHAPSFN FLSNSCWSKP KEDKAVDTSD LEVAEDPMGL
   421  QGIDLITAAL LFCLGDSPGG RGISDSRMAD IYHIDVGTQT FSLPSAILAT STMVGEIASA
   481  SACDHANPQL SNPSPFQTLG LDLVLECVAR YQPKQRSMFT FVCGQLFRRK EFSSHFKNVH
   541  GDIHAGLNGW MEQRCPLAYY GCTYSQRRFC PSIQGAKIIH DRHLRSFGVQ PCVSTVLVEP
   601  ARNCVLGLHN DHLSSLPFEV LQHIAGFLDG FSLCQLSCVS KLMRDVCGSL LQSRGMVILQ
   661  WGKRKYPEGN SSWQIKEKVW RFSTAFCSVN EWKFADILSM ADHLKKCSYN VVEKREEAIP
   721  LPCMCVTREL TKEGRSLRSV LKPVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXO30 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.49

Highest tissue expression

11 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.45

gnomAD pLI

0.36

gnomAD missense Z

1.41

DepMap mean gene effect

0.09

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• chromatin organization
• chromosome condensation
• chromosome segregation
• gene expression
• protein ubiquitination

Molecular functions

• ubiquitin protein ligase activity
• zinc ion binding

Cellular components

• cytosol

Protein domainsUniProt · Pfam · InterPro

• Zinc finger, TRAF-type
• F-box domain
• Zinc finger, RING/FYVE/PHD-type
• F-box only protein 30/40
• F-box-like domain superfamily
• Zinc finger, TRAF-type, N-terminal
• TRAF-like zinc-finger
• F-box

KeywordsUniProt

• Metal-binding
• Ubl conjugation
• Ubl conjugation pathway
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of FBXO30 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CUL1
• SKP1
• ACTB
• DYNLL1
• DYNLL2