Seroatlas · Human Serome Atlas

FARSB

Phenylalanine--tRNA ligase beta subunit

Also known as: FARSLB, FRSB, PheHB, SYFB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NSD9
Gene
FARSB
Ensembl
ENSG00000116120
Chromosome
2
Canonical length
589 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIc subfamily. This enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the presence of ATP, this tetramer is responsible for attaching L-phenylalanine to the terminal adenosine of the appropriate tRNA. A pseudogene located on chromosome 10 has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Canonical amino-acid sequenceUniProt

589 residues, UniProt reviewed canonical sequence.

>Q9NSD9|FARSB
     1  MPTVSVKRDL LFQALGRTYT DEEFDELCFE FGLELDEITS EKEIISKEQG NVKAAGASDV
    61  VLYKIDVPAN RYDLLCLEGL VRGLQVFKER IKAPVYKRVM PDGKIQKLII TEETAKIRPF
   121  AVAAVLRNIK FTKDRYDSFI ELQEKLHQNI CRKRALVAIG THDLDTLSGP FTYTAKRPSD
   181  IKFKPLNKTK EYTACELMNI YKTDNHLKHY LHIIENKPLY PVIYDSNGVV LSMPPIINGD
   241  HSRITVNTRN IFIECTGTDF TKAKIVLDII VTMFSEYCEN QFTVEAAEVV FPNGKSHTFP
   301  ELAYRKEMVR ADLINKKVGI RETPENLAKL LTRMYLKSEV IGDGNQIEIE IPPTRADIIH
   361  ACDIVEDAAI AYGYNNIQMT LPKTYTIANQ FPLNKLTELL RHDMAAAGFT EALTFALCSQ
   421  EDIADKLGVD ISATKAVHIS NPKTAEFQVA RTTLLPGLLK TIAANRKMPL PLKLFEISDI
   481  VIKDSNTDVG AKNYRHLCAV YYNKNPGFEI IHGLLDRIMQ LLDVPPGEDK GGYVIKASEG
   541  PAFFPGRCAE IFARGQSVGK LGVLHPDVIT KFELTMPCSS LEINVGPFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FARSB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 16 nTPM
  • tongue: 12 nTPM
  • cerebral cortex: 11 nTPM
  • hypothalamus: 11 nTPM
  • rectum: 11 nTPM
  • esophagus: 9.8 nTPM

Single-cell type

  • oocytes: 203 nCPM
  • erythrocyte progenitors: 110 nCPM
  • late spermatids: 101 nCPM
  • late primary spermatocytes: 101 nCPM
  • esophageal basal cells: 87 nCPM
  • epicardial cells: 86 nCPM

Immune cell

  • NK-cell: 17 nTPM
  • naive CD4 T-cell: 16 nTPM
  • memory B-cell: 15 nTPM
  • myeloid DC: 14 nTPM
  • MAIT T-cell: 14 nTPM
  • naive CD8 T-cell: 14 nTPM

Brain region

  • pons: 17 nTPM
  • hypothalamus: 17 nTPM
  • cerebellum: 16 nTPM
  • cerebral cortex: 15 nTPM
  • basal ganglia: 15 nTPM
  • medulla oblongata: 14 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FARSB.

Disease | AllUniProt

Conditions FARSB is implicated in, by any mechanism.

  • Rajab interstitial lung disease with brain calcifications 1 (RILDBC1) MIM:613658

Disease | GeneticClinVar

14 pathogenic / likely-pathogenic of 249 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Rajab interstitial lung disease with brain calcifications
  • Rajab interstitial lung disease with brain calcifications 1
  • Cerebral calcification
  • Cirrhosis of liver
  • Vascular dilatation

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.56
gnomAD pLI
0
gnomAD missense Z
1.16
DepMap mean gene effect
-1.89
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FARSB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FARSB as an antibody target. Whether an autoantibody or antibody against FARSB could matter depends on whether native FARSB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FARSB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FARSB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FARSB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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