FAM9B
Protein FAM9B
Also known as: FAM9B_HUMAN, TEX39B
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8IZU0
- Gene
- FAM9B
- Ensembl
- ENSG00000177138
- Chromosome
- X
- Canonical length
- 186 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
This gene is a member of a gene family which arose through duplication on the X chromosome. The encoded protein may be localized to the nucleus as the protein contains several nuclear localization signals, and has similarity to a synaptonemal complex protein. [provided by RefSeq, Aug 2011]
Canonical amino-acid sequenceUniProt
186 residues, UniProt reviewed canonical sequence.
>Q8IZU0|FAM9B
1 MAAWGKKHAG KDPVRDECEE RNRFTETREE DVTDEHGERE PFAETDEHTG ANTKKPEDTA
61 EDLTAKRKRM KMDKTCSKTK NKSKHALRKK QLKRQKRDYI HSLKLLNVLE EYITDEQKEE
121 EEEEGEEEEL IRIFQEQQKK WQQYRSVRRE RLKEMKLLRD QFVKALEDFE DLCDRVFSDE
181 DSELDNLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FAM9B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.56
- Highest tissue expression
- 5.9 nTPM
Expression across tissuesHPA
Tissue
- testis: 5.9 nTPM
- liver: 3.6 nTPM
- endometrium: 2 nTPM
- epididymis: 1.3 nTPM
- smooth muscle: 0.8 nTPM
- seminal vesicle: 0.6 nTPM
Single-cell type
- early primary spermatocytes: 168 nCPM
- differentiating spermatogonia: 76 nCPM
- oocytes: 69 nCPM
- epididymal principal cells: 59 nCPM
- somatotrophs: 36 nCPM
- undifferentiated spermatogonia: 20 nCPM
Immune cell
- neutrophil: 0.4 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- white matter: 2.1 nTPM
- hypothalamus: 2 nTPM
- cerebellum: 1.9 nTPM
- amygdala: 1.8 nTPM
- cerebral cortex: 1.8 nTPM
- medulla oblongata: 1.8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.69
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.63
- DepMap mean gene effect
- 0.21
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of FAM9B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FAM9B as an antibody target. Whether an autoantibody or antibody against FAM9B could matter depends on whether native FAM9B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FAM9B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FAM9B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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